Current practice of colonoscopy surveillance in patients with lynch syndrome: A multicenter retrospective cohort study in Japan.

Content Provider	Europe PMC
Author	Miyakura, Yasuyuki Chino, Akiko Tanakaya, Kohji Lefor, Alan Kawarai Akagi, Kiwamu Takao, Akinari Yamada, Masayoshi Ishida, Hideyuki Komori, Koji Sasaki, Kazuhito Miguchi, Masashi Hirata, Keiji Sudo, Tomoya Ishikawa, Toshiaki Yamaguchi, Tatsuro Tomita, Naohiro Ajioka, Yoichi
Abstract	AbstractObjectivesColonoscopy surveillance reduces the incidence of colorectal cancer through the detection and endoscopic removal of adenomas. Current guidelines recommend that patients with Lynch syndrome should have colonoscopy surveillance every 1–2 years starting at the age of 20–25. However, insufficient data are available to evaluate the quality and safety of colonoscopy surveillance for patients with Lynch syndrome nationwide in Japan.MethodsPatients with Lynch syndrome (n = 309) from 13 institutions who underwent one or more colonoscopy procedures were enrolled in this retrospective analysis. Colonoscopy completion rate, colonoscopy‐related complication rate, proportion with an adequate colonoscopy interval, and adenoma detection rate were reviewed.ResultsThe colonoscopy completion rate was 98.8% and a history of previous colorectal cancer surgery was significantly associated with a higher completion rate. All complications were associated with endoscopic treatment and the rate of bleeding needing hemostasis and perforation needing surgical repair were both 0.16% after colonoscopy with polypectomy. The adenoma detection rate at the first colonoscopy was 25%. Although there was no difference in the completion and complication rates based on differences in the colonoscopy experience of the endoscopist, the detection rate of adenomas and intramucosal cancers was significantly higher with more experienced endoscopists. The proportion of patients developing cancer was significantly higher with a >24 months than a ≤24 months interval.ConclusionHigh‐volume experienced endoscopists and appropriate surveillance intervals may minimize the risk of developing colorectal cancers in patients with Lynch syndrome.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9624071&blobtype=pdf
Page Count	9
Journal	DEN Open
Volume Number	3
DOI	10.1002/deo2.179
PubMed Central reference number	PMC9624071
Issue Number	1
PubMed reference number	36330234
e-ISSN	26924609
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-11-01
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2022 The Authors. DEN Open published by John Wiley & Sons Australia, Ltd on behalf of Japan Gastroenterological Endoscopy Society.
Subject Keyword	adenoma detection rate colonoscopy surveillance complication endoscopic interval Lynch syndrome
Content Type	Text
Resource Type	Article
Subject	Medicine