Cyclometalated iridium complexes-catalyzed acceptorless dehydrogenative coupling reaction: construction of quinoline derivatives and evaluation of their antimicrobial activities.

Content Provider	Europe PMC
Author	Shui, Hongling Zhong, Yuhong Luo, Renshi Zhang, Zhanyi Huang, Jiuzhong Yang, Ping Luo, Nianhua
Editor	Marek, Ilan
Copyright Year	2022
Abstract	The acceptorless dehydrogenative coupling (ADC) reaction is an efficient method for synthesizing quinoline and its derivatives. In this paper, various substituted quinolines were synthesized from 2-aminobenzyl alcohols and aryl/heteroaryl/alkyl secondary alcohols in one pot via a cyclometalated iridium-catalyzed ADC reaction. This method has some advantages, such as easy availability of raw materials, mild reaction conditions, wide range of substrates, and environmental friendliness which conforms to the principles of green chemistry. Furthermore, a gram-scale experiment with low catalyst loading offers the potential to access the aryl/heteroaryl quinolones in suitable amounts. In addition, the antibacterial and antifungal activities of the synthesized quinolines were evaluated in vitro, and the experimental results showed that the antibacterial activities of compounds 3ab, 3ad, and 3ah against Gram-positive bacteria and compound 3ck against C. albicans were better than the reference drug norfloxacin.
Volume Number	18
PubMed Central reference number	PMC9623133
PubMed reference number	36339464
Journal	Beilstein Journal of Organic Chemistry [Beilstein J Org Chem]
e-ISSN	18605397
DOI	10.3762/bjoc.18.159
Language	English
Publisher	Beilstein-Institut
Publisher Date	2022-10-27
Publisher Place	Germany
Access Restriction	Open
Rights License	This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material. Copyright © 2022, Shui et al.
Subject Keyword	acceptorless dehydrogenative coupling reaction antibacterial cyclometalated iridium complexes quinolines
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry