Formation of supramolecular channels by reversible unwinding-rewinding of bis(indole) double helix via ion coordination.

Content Provider	Europe PMC
Author	Mondal, Debashis Ahmad, Manzoor Dey, Bijoy Mondal, Abhishek Talukdar, Pinaki
Abstract	Stimulus-responsive reversible transformation between two structural conformers is an essential process in many biological systems. An example of such a process is the conversion of amyloid-β peptide into β-sheet-rich oligomers, which leads to the accumulation of insoluble amyloid in the brain, in Alzheimer's disease. To reverse this unique structural shift and prevent amyloid accumulation, β-sheet breakers are used. Herein, we report a series of bis(indole)-based biofunctional molecules, which form a stable double helix structure in the solid and solution state. In presence of chloride anion, the double helical structure unwinds to form an anion-coordinated supramolecular polymeric channel, which in turn rewinds upon the addition of Ag+ salts. Moreover, the formation of the anion-induced supramolecular ion channel results in efficient ion transport across lipid bilayer membranes with excellent chloride selectivity. This work demonstrates anion-cation-assisted stimulus-responsive unwinding and rewinding of artificial double-helix systems, paving way for smart materials with better biomedical applications.
Journal	Nature Communications [Nat Commun]
Volume Number	13
DOI	10.1038/s41467-022-34159-y
PubMed Central reference number	PMC9622825
Issue Number	1
PubMed reference number	36316309
e-ISSN	20411723
Language	English
Publisher	Nature Publishing Group
Publisher Date	2022-10-31
Publisher Place	London
Access Restriction	Open
Subject Keyword	Self-assembly Supramolecular polymers
Content Type	Text
Resource Type	Article
Subject	Chemistry Biochemistry, Genetics and Molecular Biology Physics and Astronomy