The Multidisciplinary Management of Perianal Fistulas in Crohn's Disease: A Systematic Review.

Content Provider	Europe PMC
Author	Badla, Omar Goit, Raman Saddik, Samia E Dawood, Sarah Rabih, Ahmad M Mohammed, Ahmad Raman, Aishwarya Uprety, Manish Calero, Maria Villanueva, Maria Resah B Joshaghani, Narges Villa, Nicole Mohammed, Lubna
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2022
Abstract	Perianal fistulas in Crohn's disease (CD) are often recurring and challenging to treat. This systematic review aimed to evaluate the medical, surgical, and combination treatment options and provide an overview of their efficacy. We performed this systematic review following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Our group searched PubMed, Medline, PubMed Central, Google Scholar, and ScienceDirect for articles within the last ten years using different terms and criteria mentioned in detail in the search strategy and eligibility criteria sections. Initially, 739 records were retrieved, out of which we excluded 731 records for various reasons, such as irrelevant titles and abstracts and low scores on quality assessment tools. The evidence for combination (surgical and medical) therapy is superior to that for medical and surgical treatments individually. In contrast, the studies on medical and surgical treatments individually reported varied evidence and efficacy for their respective options.
Journal	Cureus
Volume Number	14
DOI	10.7759/cureus.29347
PubMed Central reference number	PMC9582904
Issue Number	9
PubMed reference number	36284816
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2022-09-20
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	perianal fistula medical and surgical management treatment options of perianal fistula in crohn’s disease perianal fistula in crohn’s disease crohn’s disease (cd)
Content Type	Text
Resource Type	Article
Subject	Medicine