Serum TRAIL predicts severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study.

Content Provider	Europe PMC
Author	Hua, Dong-Xu Ma, Kai-Shu Cheng, Jia-Yi Liu, Ying Sun, Jing He, Qi-Yuan Deng, You-Peng Yang, Jin Fu, Lin Zhao, Hui
Abstract	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) can trigger the apoptosis pathways through binding to relative death receptors. However, the relationship of TRAIL with community-acquired pneumonia (CAP) was unclear. This study aims at exploring the relationships between circulatory TRAIL with severity and prognosis in CAP patients through a prospective cohort study. The whole of 239 CAP patients was enrolled. Demographic characteristics and clinical information were analyzed. TRAIL and inflammatory cytokines were measured using enzyme-linked immunosorbent assay (ELISA). Circulatory TRAIL was gradually increased in accord with CAP severity scores. Spearman or Pearson correlative analysis indicated that circulatory TRAIL was strongly associated with physiologic indicators among CAP patients. Mixed logistic and linear regression models revealed that circulatory TRAIL was positively correlated with the severity scores in CAP patients. After adjusting for confounders, higher levels of circulatory TRAIL on admission significantly elevated the risks of ICU admission, mechanical ventilation, longer hospital stays, or even death during hospitalization. The predictive capacities of serum TRAIL for death were higher compared with CAP severity scores, inflammatory and infectious indicators. There are obviously positive dose-response relationships between circulatory TRAIL on admission with the severity and poor prognostic outcomes in CAP patients. Circulatory TRAIL on admission may be used as a potential biomarker in predicting the severity and poor prognosis for CAP patients.Supplementary InformationThe online version contains supplementary material available at 10.1007/s11739-022-03086-7.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9569003&blobtype=pdf
ISSN	18280447
Journal	Internal and Emergency Medicine [Intern Emerg Med]
Volume Number	17
DOI	10.1007/s11739-022-03086-7
PubMed Central reference number	PMC9569003
Issue Number	8
PubMed reference number	36241932
e-ISSN	19709366
Language	English
Publisher	Springer International Publishing
Publisher Date	2022-10-14
Publisher Place	Gewerbestrasse 11, Cham, Ch 6330, Switzerland
Access Restriction	Open
Rights License	This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI) 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Subject Keyword	TRAIL Community-acquired pneumonia Severity Prognosis Prospective cohort study
Content Type	Text
Resource Type	Article
Subject	Emergency Medicine Internal Medicine