Association of Cardiac Biomarkers With Cardiovascular Outcomes in Patients With Psoriatic Arthritis and Psoriasis: A Longitudinal Cohort Study.

Content Provider	Europe PMC
Author	Colaco, Keith Lee, Ker‐Ai Akhtari, Shadi Winer, Raz Welsh, Paul Sattar, Naveed McInnes, Iain B. Chandran, Vinod Harvey, Paula Cook, Richard J. Gladman, Dafna D. Piguet, Vincent Eder, Lihi
Abstract	ObjectiveIn patients with psoriatic disease (PsD), we determined whether cardiac troponin I (cTnI) and N‐terminal pro–brain natriuretic peptide (NT‐proBNP) were associated with carotid plaque burden and the development of cardiovascular events independent of the Framingham Risk Score (FRS).MethodsAmong 1,000 patients with PsD, carotid total plaque area (TPA) was measured in 358 participants at baseline. Cardiac troponin I and NT‐proBNP were measured using automated clinical assays. The association between cardiac biomarkers and carotid atherosclerosis was assessed by multivariable regression after adjusting for cardiovascular risk factors. Improvement in the prediction of cardiovascular events beyond the FRS was tested using measures of risk discrimination and reclassification.ResultsIn univariate analyses, cTnI (β coefficient 0.52 [95% confidence interval (95% CI) 0.3, 0.74], P < 0.001) and NT‐proBNP (β coefficient 0.24 [95% CI 0.1, 0.39], P < 0.001) were associated with TPA. After adjusting for cardiovascular risk factors, the association remained statistically significant for cTnI (adjusted β coefficient 0.21 [95% CI 0, 0.41], P = 0.047) but not for NT‐proBNP (P = 0.21). Among the 1,000 patients with PsD assessed for cardiovascular risk prediction, 64 patients had incident cardiovascular events. When comparing a base model (with the FRS alone) to expanded models (with the FRS plus cardiac biomarkers), there was no improvement in predictive performance.ConclusionIn patients with PsD, cTnI may reflect the burden of atherosclerosis, independent of traditional cardiovascular risk factors. Cardiac troponin I and NT‐proBNP are associated with incident cardiovascular events independent of the FRS, but further study of their role in cardiovascular risk stratification is warranted.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9545279&blobtype=pdf
Page Count	9
ISSN	23265191
Journal	Arthritis & Rheumatology (Hoboken, N.j.) [Arthritis Rheumatol]
Volume Number	74
DOI	10.1002/art.42079
PubMed Central reference number	PMC9545279
Issue Number	7
PubMed reference number	35261189
e-ISSN	23265205
Language	English
Publisher	Wiley Periodicals, Inc.
Publisher Date	2022-05-16
Publisher Place	Boston, USA
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Rheumatology