NDLI: New Perspectives on Immune Involvement in Parkinson's Disease Pathogenesis.

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New Perspectives on Immune Involvement in Parkinson's Disease Pathogenesis.

Content Provider	Europe PMC
Author	Gate, David
Editor	Bloem, Bastiaan R. Brundin, Patrik Tan, Eng King Harms, Ashley Lindestam Arlehamn, Cecilia Williams-Gray, Caroline
Copyright Year	2022
Abstract	Accumulating evidence implicates immune dysfunction in the etiology of Parkinson’s disease (PD). For instance, impaired cellular and humoral immune responses are emerging as established pathological hallmarks in PD. Further, in experimental models of PD, inflammatory cell activation and immune dysregulation are evident. Genetic and epidemiologic studies have drawn associations between autoimmune disease and PD. Distillation of these various lines of evidence indicates dysregulated immunogenetics as a primary risk factor for PD. This article will present novel perspectives on the association between genetic risk factors and immune processes in PD. The objective of this work is to synthesize the data surrounding the role of immunogenetics in PD to maximize the potential of targeting the immune system as a therapeutic modality.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9535554&blobtype=pdf
ISSN	18777171
Journal	Journal of Parkinson's Disease [J Parkinsons Dis]
Volume Number	12
PubMed Central reference number	PMC9535554
Issue Number	Suppl 1
Issue Number	s1
PubMed reference number	35811535
e-ISSN	1877718X
DOI	10.3233/jpd-223240
Language	English
Publisher	IOS Press
Publisher Date	2022-01-01
Publisher Place	Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2022 – The authors. Published by IOS Press
Subject Keyword	Parkinson’s disease immune T cells adaptive immunity immunogenetics
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Cellular and Molecular Neuroscience

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