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Bifidobacterium longum and Galactooligosaccharide Improve Skin Barrier Dysfunction and Atopic Dermatitis-like Skin.
| Content Provider | Europe PMC |
|---|---|
| Author | Kim, Sukyung Han, Song-Yi Lee, Jinyoung Kim, Na-Rae Lee, Bo Ra Kim, Hyunmi Kwon, Mijeoung Ahn, Kangmo Noh, Youngbae Kim, Sang Jong Lee, Phyrim Kim, Dongki Kim, Byung Eui Kim, Jihyun |
| Copyright Year | 2022 |
| Abstract | PurposeThe beneficial effects of a combination therapy using Bifidobacterium longum and galactooligosaccharide (GOS) for the treatment of atopic dermatitis (AD) have not been elucidated.MethodsGene expressions of interleukin (IL)-4 and IL-13 from peripheral blood mononuclear cells and fecal abundance of B. longum from 12-month-old infants were evaluated. Human primary epidermal keratinocytes (HEKs) and hairless mice were treated with B. longum, GOS, B. longum-derived extracellular vesicles (BLEVs), dinitrochlorobenzene (DNCB), or a synbiotic mixture of B. longum and GOS. Expression of epidermal barrier proteins and cytokines as well as serum immunoglobulin E (IgE) levels were analyzed in HEKs and mice. Dermatitis scores, transepidermal water loss (TEWL), epidermal thickness, and fecal B. longum abundance were evaluated in mice.ResultsFecal abundance of B. longum was negatively correlated with blood IL-13 expression in infants. B. longum or BLEVs increased expression of filaggrin (FLG) and loricrin (LOR) in HEKs. B. longum increased the efficacy of GOS to upregulate FLG and LOR expressions in HEKs. Oral administration of GOS increased fecal abundance of B. longum in mice. Oral administration of B. longum attenuated DNCB-induced skin inflammation, abnormal TEWL, AD-like skin, and deficiency of epidermal barrier proteins. Moreover, the combination of B. longum and GOS showed greater effects to improve DNCB-induced skin inflammation, abnormal TEWL, AD-like skin, serum IgE levels, IL-4 over-expression, and the deficiency of epidermal barrier proteins than the administration of B. longum alone.ConclusionsB. longum and GOS improve DNCB-induced skin barrier dysfunction and AD-like skin. |
| ISSN | 20927355 |
| Journal | Allergy, Asthma & Immunology Research |
| Volume Number | 14 |
| PubMed Central reference number | PMC9523416 |
| Issue Number | 5 |
| PubMed reference number | 36174995 |
| e-ISSN | 20927363 |
| DOI | 10.4168/aair.2022.14.5.549 |
| Language | English |
| Publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
| Publisher Date | 2022-09-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2022 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease |
| Subject Keyword | Atopic dermatitis Bifidobacterium longum prebiotics probiotics synbiotics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Immunology |
