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Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential.
| Content Provider | Europe PMC |
|---|---|
| Author | Yan, Shuaifeng Kotschenreuther, Konstantin Deng, Shuya Kofler, David M. |
| Abstract | Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are thought to play a vital role in disease onset. In the pathogenesis of autoimmune diseases, disturbed immunosuppressive properties of regulatory T cells contribute to the dysregulation of immune homeostasis. In RA patients, the functions of Treg cells and their frequency are reduced. Therefore, focusing on the re-establishment of self-tolerance by increasing Treg cell frequencies and preventing a loss of function is a promising strategy for the treatment of RA. This approach could be especially beneficial for those patients who do not respond well to current therapies. In this review, we summarize and discuss the current knowledge about the function, differentiation and regulation of Treg cells in RA patients and in animal models of autoimmune arthritis. In addition, we highlight the therapeutic potential as well as the challenges of Treg cell targeting treatment strategies. |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 79 |
| PubMed Central reference number | PMC9522664 |
| Issue Number | 10 |
| PubMed reference number | 36173485 |
| e-ISSN | 14209071 |
| DOI | 10.1007/s00018-022-04563-0 |
| Language | English |
| Publisher | Springer International Publishing |
| Publisher Date | 2022-09-29 |
| Publisher Place | Gewerbestrasse 11, Cham, Ch 6330, Switzerland |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2022 |
| Subject Keyword | Regulatory T cells Chimeric antigen receptor CD4+ T cells Therapeutic potential Self-tolerance Autoimmunity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
