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Tranexamic Acid and Intraoperative and Postoperative Accumulative Bleeding in Elective Degenerative Spine Surgery.
| Content Provider | Europe PMC |
|---|---|
| Author | Abdou, Mahmoud Kwon, Ji-Won Kim, Hye Jin Lee, Bora Choi, Yong Seon Moon, Seong-Hwan Lee, Byung Ho |
| Copyright Year | 2022 |
| Abstract | PurposeSpinal surgeries are often associated with a high incidence of perioperative blood loss, which poses several complications. Much current research focuses on the importance of antifibrinolytic drugs during spinal surgeries to reduce blood loss, which can also reduce the risk of the need for blood transfusions. We evaluated the effects of prophylactic, low-dose tranexamic acid (TXA) in spinal fusion surgeries on blood loss, blood transfusions, and associated complications.Materials and MethodsTXA was administered to 90 patients at a constant infusion rate of 10 mg/kg for 20 minutes after anesthesia induction, followed by a maintenance dose of 1 mg/kg/h until the end of the operation. An additional 91 patients were included as controls.ResultsThere were no significant differences between the study groups in terms of intraoperative blood loss, which was 500 mL for both groups (p>0.999). Also, intraoperative blood transfusion requirements were similar between both groups (p=0.330). Mean blood transfusion amounts were 125±35 mL for patients in the TXA group and 85±25 mL in the control group. However, there was a significant reduction in postoperative blood transfusion (p=0.003) in the TXA group. Only three cases in the TXA group required blood transfusion, while 15 cases in the control group did.ConclusionWe confirmed that low dose TXA has no effect on intraoperative blood loss volume or blood transfusion requirements and that it can significantly reduce the need for postoperative blood transfusions. |
| ISSN | 05135796 |
| Volume Number | 63 |
| PubMed Central reference number | PMC9520043 |
| Issue Number | 10 |
| PubMed reference number | 36168245 |
| Journal | Yonsei Medical Journal [Yonsei Med. J] |
| e-ISSN | 19762437 |
| DOI | 10.3349/ymj.2022.0163 |
| Language | English |
| Publisher | Yonsei University College of Medicine |
| Publisher Date | 2022-10-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2022 |
| Subject Keyword | Blood loss blood transfusion intraoperative PLIF postoperative tranexamic acid |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
