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Specialized inpatient treatment for young people with early psychosis: acute-treatment and 12-month results.
| Content Provider | Europe PMC |
|---|---|
| Author | Siebert, Stefan Leopold, Karolina Baumgardt, Johanna von Hardenberg, Laura-Sophie Burkhardt, Eva Bechdolf, Andreas |
| Abstract | The objective of the study was to investigate the development of clinical outcomes of young people with early psychosis in a specialized inpatient treatment and assess the feasibility of such an intervention in an inpatient setting. The study was a prospective cohort study of patients with early psychosis treated at the specialized inpatient treatment “Fühinterventions-und Therapiezentrum, FRITZ” (early intervention and therapy center) in Berlin, Germany. The primary outcomes were attitudes towards psychiatric medication and patient satisfaction with treatment after 6 weeks. Secondary outcomes were clinical symptoms, functioning, remission, recovery, all-cause treatment discontinuation, and rehospitalisation at 6 and 12 months after inpatient treatment. We recruited 95 inpatients with early psychosis. Attitudes towards psychiatric medication (Δ6weeks = 3.00, d6weeks = 0.55; Δ6mo = 2.15, d6mo = 0.35; Δ12mo = 3.03, d12mo = 0.52) and patient satisfaction (Δ6weeks = 0.21, d6weeks = 0.40; Δ6mo = 0.32, d6mo = 0.43; Δ12mo = 0.13, d12mo = 0.17) changed with medium effect sizes at six weeks up to a 6- and 12-month follow-up. Clinical outcomes changed significantly with medium-to-large-effect sizes over 12 months CGIΔ12mo = 1.64, d12mo = −1.12; PANSS totalΔ12mo = 20.10, d12mo = −0.76; GAFΔ12mo = 19.58, d12mo = 1.25). The all-cause treatment discontinuation rate was 13.69% (n = 13) at a 6-month and 35.79% (n = 34) at a 12-month follow-up. The rehospitalization rate was 30.53% (n = 29) at a 6-month and 43.16% (n = 41) at a 12-month follow-up. Patients with specialized inpatient treatment for early psychosis showed improvements in attitude towards psychiatric medication, patient satisfaction, symptoms, and functioning for up to 12 months.Trial registration: DRKS00024351, 2021/02/11 retrospectively registered.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00406-022-01379-8. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9508217&blobtype=pdf |
| ISSN | 09401334 |
| Journal | European Archives of Psychiatry and Clinical Neuroscience [Eur Arch Psychiatry Clin Neurosci] |
| Volume Number | 272 |
| DOI | 10.1007/s00406-022-01379-8 |
| PubMed Central reference number | PMC9508217 |
| Issue Number | 7 |
| PubMed reference number | 35141809 |
| e-ISSN | 14338491 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2022-02-09 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2022 |
| Subject Keyword | Early intervention Early psychosis Psychosis Inpatient treatment Psychotherapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Pharmacology (medical) Psychiatry and Mental Health |
