NDLI: Cor Pulmonale Secondary to Severe Pulmonary Hypertension As the First Manifestation of Graves' Disease.

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Cor Pulmonale Secondary to Severe Pulmonary Hypertension As the First Manifestation of Graves' Disease.

Content Provider	Europe PMC
Author	Santos, Sandra D Lopes Sousa, David Cristina Martins, Ana Rua, João Ribeiro, Pedro
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2022
Abstract	Pulmonary hypertension (PH), especially if severe, carries a significant morbidity and mortality. Herein we describe a case of an 88-year-old woman with severe heart failure and several hospitalizations that year for the same reason, rapid re-admission after discharge and loss of walking ability. Transthoracic echocardiography (TTE) revealed severe pulmonary hypertension (PASP=69 mmHg) and right ventricular dysfunction without left structural or functional dysfunction. Pulmonary thromboembolism, relevant pulmonary pathology was excluded, and an extended autoimmune study was also negative. Thyroid disorders were investigated, a Graves' disease with thyrotoxicosis was diagnosed and promptly treated with thiamazole, also known as methimazole. There was a rapid improvement in the clinical and hemodynamic status of the patient, stabilization of the right heart failure (HF), resolution of the volume overload and a TTE showed improvement with moderate PH (PASP=55 mmHg). This case shows a reversible cause of PH and highlights how treatment of Graves' disease can reduce pulmonary artery pressure and contribute to symptomatic relief and better quality of life.
Journal	Cureus
Volume Number	14
DOI	10.7759/cureus.28115
PubMed Central reference number	PMC9484789
Issue Number	8
PubMed reference number	36158390
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2022-08-17
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	trabs quality of life heart failure graves' disease pulmonary hypertension
Content Type	Text
Resource Type	Case study
Subject	Medicine

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