Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis.

Content Provider	Europe PMC
Author	Dixon, Matthew A Winskill, Peter Harrison, Wendy E Whittaker, Charles Schmidt, Veronika Flórez Sánchez, Astrid Carolina Cucunuba, Zulma M Edia-Asuke, Agnes U Walker, Martin Basáñez, María-Gloria
Editor	Ferreira, Marcelo U Davenport, Miles P
Copyright Year	2022
Abstract	Infection by Taenia solium poses a major burden across endemic countries. The World Health Organization (WHO) 2021–2030 Neglected Tropical Diseases roadmap has proposed that 30% of endemic countries achieve intensified T. solium control in hyperendemic areas by 2030. Understanding geographical variation in age-prevalence profiles and force-of-infection (FoI) estimates will inform intervention designs across settings. Human taeniasis (HTT) and human cysticercosis (HCC) age-prevalence data from 16 studies in Latin America, Africa, and Asia were extracted through a systematic review. Catalytic models, incorporating diagnostic performance uncertainty, were fitted to the data using Bayesian methods, to estimate rates of antibody (Ab)-seroconversion, infection acquisition and Ab-seroreversion or infection loss. HCC FoI and Ab-seroreversion rates were also estimated across 23 departments in Colombia from 28,100 individuals. Across settings, there was extensive variation in all-ages seroprevalence. Evidence for Ab-seroreversion or infection loss was found in most settings for both HTT and HCC and for HCC Ab-seroreversion in Colombia. The average duration until humans became Ab-seropositive/infected decreased as all-age (sero)prevalence increased. There was no clear relationship between the average duration humans remain Ab-seropositive and all-age seroprevalence. Marked geographical heterogeneity in T. solium transmission rates indicate the need for setting-specific intervention strategies to achieve the WHO goals.
Journal	eLife
Volume Number	11
PubMed Central reference number	PMC9391040
PubMed reference number	35984416
e-ISSN	2050084X
DOI	10.7554/elife.76988
Language	English
Publisher	eLife Sciences Publications, Ltd
Publisher Date	2022-08-19
Access Restriction	Open
Rights License	This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. © 2022, Dixon et al
Subject Keyword	taenia solium one health modelling neglected tropical diseases statistics zoonotic infections
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Neuroscience Medicine Biochemistry, Genetics and Molecular Biology