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Effects of acute intermittent hypoxia on corticospinal excitability within the primary motor cortex.
| Content Provider | Europe PMC |
|---|---|
| Author | Radia, Shivani Vallence, Ann-Maree Fujiyama, Hakuei Fitzpatrick, Rose Etherington, Sarah Scott, Brendan R. Girard, Olivier |
| Abstract | PurposeAcute intermittent hypoxia (AIH) is a safe and non-invasive treatment approach that uses brief, repetitive periods of breathing reduced oxygen air alternated with normoxia. While AIH is known to affect spinal circuit excitability, the effects of AIH on cortical excitability remain largely unknown. We investigated the effects of AIH on cortical excitability within the primary motor cortex.MethodsEleven healthy, right-handed participants completed two testing sessions: (1) AIH (comprising 3 min in hypoxia [fraction of inspired oxygen ~ 10%] and 2 min in normoxia repeated over five cycles) and (2) normoxia (NOR) (equivalent duration to AIH). Single- and paired-pulse transcranial magnetic stimulations were delivered to the primary motor cortex, before and 0, 25, and 50 min after AIH and normoxia.ResultsThe mean nadir in arterial oxygen saturation was lower (p < 0.001) during the cycles of AIH (82.5 ± 4.9%) than NOR (97.8 ± 0.6%). There was no significant difference in corticospinal excitability, intracortical facilitation, or intracortical inhibition between AIH and normoxia conditions at any time point (all p > 0.05). There was no association between arterial oxygen saturation and changes in corticospinal excitability after AIH (r = 0.05, p = 0.87).ConclusionOverall, AIH did not modify either corticospinal excitability or excitability of intracortical facilitatory and inhibitory circuits within the primary motor cortex. Future research should explore whether a more severe or individualised AIH dose would induce consistent, measurable changes in corticospinal excitability.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00421-022-04982-8. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9381468&blobtype=pdf |
| ISSN | 14396319 |
| Journal | European Journal of Applied Physiology [Eur J Appl Physiol] |
| Volume Number | 122 |
| DOI | 10.1007/s00421-022-04982-8 |
| PubMed Central reference number | PMC9381468 |
| Issue Number | 9 |
| PubMed reference number | 35752660 |
| e-ISSN | 14396327 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2022-06-25 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2022 |
| Subject Keyword | Acute intermittent hypoxia Corticospinal excitability Transcranial magnetic stimulation Primary motor cortex Intracortical inhibition |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science |
