Notoginsenoside R1 alleviates spinal cord injury by inhibiting oxidative stress, neuronal apoptosis, and inflammation via activating the nuclear factor erythroid 2 related factor 2/heme oxygenase-1 signaling pathway.

Content Provider	Europe PMC
Author	Luo, Hongbo Bao, Zhangli Zhou, Mingjian Chen, Yuxin Huang, Zhaoxi
Copyright Year	2022
Abstract	The secondary injury plays a vital role in the development of spinal cord injury (SCI), which is characterized by the occurrence of oxidative stress, neuronal apoptosis, and inflammatory response. Notoginsenoside R1 (NGR1) has been involved in the modulation of antioxidative stress and anti-inflammatory response. However, its roles in SCI-induced injury are still unknown. We explored the therapeutic effect of NGR1 and its underlying mechanism after SCI by using behavioral, biochemical, and immunohistochemical techniques. The administration of NGR1 after SCI enhanced the neurological function, and mitigated tissue damage and motor neuron loss than those in SCI + vehicle group. Meanwhile, significantly increased expression of Nrf2 protein and HO-1 protein was found in the SCI + NGR1 group compared with those in the SCI + vehicle group. In addition, the inhibitory effects of oxidative stress, apoptotic neuron ratio, and neuronal inflammation in the SCI + NGR1 group can be partially reversed when the Nrf2/HO-1 signaling pathway was inhibited by ML385. Our results indicate that the administration of NGR1 can attenuate oxidative stress, neuronal apoptosis, and inflammation by activating the Nrf2/HO-1 signaling pathway after SCI, thereby improving neurological function.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9354723&blobtype=pdf
ISSN	09594965
Journal	Neuroreport
Volume Number	33
PubMed Central reference number	PMC9354723
Issue Number	11
PubMed reference number	35775321
e-ISSN	1473558X
DOI	10.1097/wnr.0000000000001803
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2022-06-27
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
Subject Keyword	apoptosis notoginsenoside R1 Nrf2/HO-1 pathway oxidative stress spinal cord injury
Content Type	Text
Resource Type	Article
Subject	Neuroscience