The vaccination status and adverse effects of COVID-19 vaccine among pregnant women in Japan in 2021.

Content Provider	Europe PMC
Author	Komine‐Aizawa, Shihoko Haruyama, Yasuo Deguchi, Masashi Hayakawa, Satoshi Kawana, Kei Kobashi, Gen Miyagi, Etsuko Yamada, Hideto Sugiyama, Takashi
Abstract	AbstractTo investigate the vaccination status and adverse reactions to the COVID‐19 vaccine among pregnant women in Japan, we conducted an online questionnaire survey from October 5 to November 22, 2021. The number of participants in the online survey was 6576. Of the participants, 4840 (73.6%) were vaccinated twice, and 557 (8.5%) were vaccinated once. A total of 1179 (17.9%) responders had never been vaccinated against COVID‐19. The most frequent adverse reaction was local pain at the injection site. The incidence of local adverse reactions was almost identical after the first and the second vaccinations, while systemic reactions, such as fever and fatigue/malaise, and adverse reactions outside the vaccination site such as headache and arthralgia, were more frequent after the second vaccination than after the first vaccination. Regarding the obstetrical complications, uterine tension and/or contraction was observed in 1.65% of the pregnant women after the first vaccination and in 2.98% after the second vaccination, and uterine pain appeared in 1.06% of the pregnant women after the second vaccination. However, serious symptoms, such as hemorrhage, decreased fetal movement, edema, increased blood pressure, and amniorrhexis, were seen in less than 1% of vaccinated women after both the first and second vaccinations. This study clarified the characteristics of vaccination, adverse reactions, and obstetrical symptoms in pregnant women in Japan who had the COVID‐19 vaccine up to the second dose. As a booster vaccination is currently underway, further study is needed to improve the management of pregnant women during the current pandemic.
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Page Count	9
ISSN	13418076
Journal	The Journal of Obstetrics and Gynaecology Research [J Obstet Gynaecol Res]
Volume Number	48
DOI	10.1111/jog.15285
PubMed Central reference number	PMC9347631
Issue Number	7
PubMed reference number	35537777
e-ISSN	14470756
Language	English
Publisher	John Wiley & Sons Australia, Ltd
Publisher Date	2022-05-10
Publisher Place	Kyoto, Japan
Access Restriction	Open
Rights License	This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency. © 2022 Japan Society of Obstetrics and Gynecology.
Subject Keyword	adverse reaction COVID‐19 mRNA vaccine pregnancy vaccination
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology