Effects of omega-3 fatty acid on major cardiovascular outcomes: A systematic review and meta-analysis.

Content Provider	Europe PMC
Author	Yu, Fangyu Qi, Shun Ji, Yanan Wang, Xizhi Fang, Shaohong Cao, Ruokui
Copyright Year	2022
Abstract	Background:The effects of omega-3 fatty acid on cardiovascular health obtained inconsistent results. A systematic review and meta-analysis were therefore conducted to assess the effects of omega-3 fatty acid supplementation for primary and secondary prevention strategies of major cardiovascular outcomes.Methods:The databases of PubMed, Embase, and the Cochrane library were systematically searched from their inception until September 2020. Relative risks (RRs) with 95% confidence intervals were used to assess effect estimates by using the random-effects model.Results:Twenty-eight randomized controlled trials involving 136,965 individuals were selected for the final meta-analysis. Omega-3 fatty acid was noted to be associated with a lower risk of major cardiovascular events (RR, 0.94; 95% CI, 0.89–1.00; P = .049) and cardiac death (RR, 0.92; 95% CI, 0.85–0.99; P = .022). However, no significant differences was noted between omega-3 fatty acid and the control for the risks of all-cause mortality (RR, 0.97; 95% CI, 0.92–1.03; P = .301), myocardial infarction (RR, 0.90; 95% CI, 0.80–1.01; P = .077), and stroke (RR, 1.02; 95% CI, 0.94–1.11; P = .694).Conclusions:Major cardiovascular events and cardiac death risks could be avoided with the use of omega-3 fatty acid. However, it has no significant effects on the risk of all-cause mortality, myocardial infarction, and stroke.
ISSN	00257974
Journal	Medicine
Volume Number	101
PubMed Central reference number	PMC9333496
Issue Number	30
PubMed reference number	35905212
e-ISSN	15365964
DOI	10.1097/md.0000000000029556
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2022-07-29
Publisher Place	Hagerstown, MD
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
Subject Keyword	omega-3 fatty acid cardiovascular disease meta-analysis
Content Type	Text
Resource Type	Article
Subject	Medicine