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Photo-activated chromophore for infectious keratitis cross-linking and its efficacy as a treatment modality in managing microbial keratitis.
| Content Provider | Europe PMC |
|---|---|
| Author | Saini, Sanchita Singh, Satyaprakash Dwivedi, Kshama Singh, Sanskriti Kumar, Santosh Rana, Jagriti |
| Copyright Year | 2022 |
| Abstract | Purpose:To assess Photo Activated Chromophore for Infective Keratitis-Cross Linking (PACK-CXL) and its efficacy as a treatment modality in managing microbial keratitis.Methods:Single Centre prospective interventional study in infectious keratitis. A total of eleven patients were taken who had corneal thickness (CT) more than 400µm. PACK-CXL was performed according to Dresden’s protocol. The response was assessed by slit lamp examination, BCVA and AS-OCT at the time of complete healing.Results:The mean visual acuity at presentation was 1.207logMAR (0.3-3) which improved to mean value of 0.53logMAR (0.3-1). Mean time taken for complete epithelization was 17.45 days (14- 30 days) and that for complete healing was 33.72 days (21- 60 days). Mean CT at the baseline was 650.5± 108µm which reduced on consecutive follow up visits. There was reduction in the symptoms in nine patients except in two. One case reported increase in symptoms with worsening increase in endoexudates and hypopyon, and the other developed drug toxicity due to topical medications.Conclusion:Patients who underwent PACK-CXL showed good and early healing, good remodelling of cornea and improved visual acuity. The recalcitrant cases became responders to the same medications after PACK-CXL. Thus, PACK-CXL works well for both fungal and bacterial keratitis. |
| ISSN | 03014738 |
| Journal | Indian Journal of Ophthalmology |
| Volume Number | 70 |
| PubMed Central reference number | PMC9333004 |
| Issue Number | 5 |
| PubMed reference number | 35502028 |
| e-ISSN | 19983689 |
| DOI | 10.4103/ijo.ijo_2693_21 |
| Language | English |
| Publisher | Wolters Kluwer - Medknow |
| Publisher Date | 2022-05-01 |
| Publisher Place | India |
| Access Restriction | Open |
| Rights License | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Copyright: © 2022 Indian Journal of Ophthalmology |
| Subject Keyword | Collagen crosslinking corneal ulcer fungal keratitis keratitis PACK-CXL |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
