Use of inhaled antibiotics among Danish patients with cystic fibrosis.

Content Provider	Europe PMC
Author	Møller, Rikke Nielsen, Bibi Uhre Faurholt‐Jepsen, Daniel Katzenstein, Terese Lea Skov, Marianne Philipsen, Lue Katrine Drasbæk Pressler, Tacjana Johansen, Helle Krogh Qvist, Tavs
Abstract	AbstractBackgroundInhaled antibiotics are an important part of cystic fibrosis (CF) airway disease management and should be individualized to fit the microorganism and match patient needs. To investigate the implementation of personalized treatment, this study mapped the use of different types of inhaled antibiotics and adherence patterns.MethodsWe performed individual structured interviews in a cross‐sectional study at the CF Centre in Copenhagen, Denmark. Patients with CF older than 15 years attending clinical consultations were included. Clinical data were obtained from centralized databases.ResultsAmong 149 participants, 107 (72%) had indication for treatment with inhaled antibiotics. In this group, 97 (91%) reported the use of inhaled antibiotics within the last 12 months. Change from one inhaled antibiotic to another during that period was reported by 31 (29%), and 17 (25%) with Pseudomonas aeruginosa had used off‐label antibiotics. Adherence to a minimum of one daily dose of antibiotic was reported by 78%, while adherence to all daily doses was 28 percentage points lower. Skipping inhalations was due to side effects and doubt about the effect in less than 5% of cases.ConclusionChange of inhaled antibiotics and use of off‐label antibiotics for inhalation were common and side effects were a rare cause of nonadherence. This suggests satisfactory implementation of the principle of tailored antibiotic inhalation prescription in the Copenhagen CF population. Adherence to at least one daily inhalation dose was markedly higher than adherence to multiple daily inhalations.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9324817&blobtype=pdf
Page Count	9
ISSN	87556863
Journal	Pediatric Pulmonology [Pediatr Pulmonol]
Volume Number	57
DOI	10.1002/ppul.25942
PubMed Central reference number	PMC9324817
Issue Number	7
PubMed reference number	35478387
e-ISSN	10990496
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-05-14
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.
Subject Keyword	adherence compliance inhalation nebulized
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Pediatrics, Perinatology and Child Health