Feasibility evaluation of the transapical saddle-shaped valved stent for transcatheter mitral valve implantation.

Content Provider	Europe PMC
Author	Wu, Kaiqin Gu, Shaorui Lu, Tiancheng Dong, Shengting Dong, Chenglai Huang, Haitao Liu, Zhenchuan Zhang, Xin Zhou, Yongxin
Abstract	AbstractBackground and Aims of StudyTranscatheter mitral valve implantation (TMVI) is a promising and minimally invasive treatment for high‐risk mitral regurgitation. We aimed to investigate the feasibility of a novel self‐expanding valved stent for TMVI via apical access.MethodsWe designed a novel self‐expanding mitral valve stent system consisting of an atrial flange and saddle‐shaped ventricular body connected by two opposing anchors and two opposing extensions. During valve deployment, each anchor was controlled by a recurrent string. TMVI was performed in 10 pigs using the valve prosthesis through apical access to verify technical feasibility. Echocardiography and ventricular angiography were used to assess hemodynamic data and valve function. Surviving pigs were killed 4 weeks later to confirm stent deployment.ResultsTen animals underwent TMVI using the novel mitral valve stent. Optimal valve deployment and accurate anatomical adjustments were obtained in nine animals. Implantation failed in one case, and the animal died 1 day later due to stent mismatch. After stent implantation, the hemodynamic parameters of the other animals were stable, and valve function was normal. The mean pressure across the mitral valve and left ventricular outflow tract were 2.98 ± 0.91 mmHg and 3.42 ± 0.66 mmHg, respectively. Macroscopic evaluation confirmed the stable and secure positioning of the stents. No obvious valve displacement, embolism, or paravalvular leakage was observed 4 weeks postvalve implantation.ConclusionsThis study demonstrated that the novel mitral valve is technically feasible in animals. However, the long‐term feasibility and durability of this valved stent must be improved and verified.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9315026&blobtype=pdf
Page Count	7
ISSN	08860440
Journal	Journal of Cardiac Surgery [J Card Surg]
Volume Number	37
DOI	10.1111/jocs.16426
PubMed Central reference number	PMC9315026
Issue Number	6
PubMed reference number	35315544
e-ISSN	15408191
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-03-22
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. Journal of Cardiac Surgery published by Wiley Periodicals LLC.
Subject Keyword	mitral regurgitation transcatheter mitral valve implantation valve prosthesis
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Surgery Cardiology and Cardiovascular Medicine