NDLI: Intensified-Dose Chemotherapy in Combination With Gemtuzumab-Ozogamicin for the Treatment of Favorable-Risk Acute Myeloid Leukemia (AML).

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Intensified-Dose Chemotherapy in Combination With Gemtuzumab-Ozogamicin for the Treatment of Favorable-Risk Acute Myeloid Leukemia (AML).

Content Provider	Europe PMC
Author	Vegunta, Rathnamitreyee Harel, Ronen Steinberg, Amir
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2022
Abstract	Chemotherapy has been the standard of treatment for acute myeloid leukemia (AML). With the emergence of new therapies for AML like gemtuzumab-ozogamicin and FLT3 inhibitors, such as sorafenib, midostaurin, and gilteritinib, the optimal dose of chemotherapy and safety profile in different age groups when combined with these new therapies is yet to be established. There are limited data on the treatment of AML by combining intensified daunorubicin (doses of 90 mg/m²) with gemtuzumab-ozogamicin (GO). We report a young adult with favorable-risk AML treated with daunorubicin at a dose of 90 mg/m² combined with GO, who had a complete response after induction but had a profound nadir of platelet count after induction and consolidation.
Journal	Cureus
Volume Number	14
DOI	10.7759/cureus.26240
PubMed Central reference number	PMC9308398
Issue Number	6
PubMed reference number	35898381
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2022-06-23
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	thrombocytopenia npm1 gemtuzumab – ozogamicin intensified daunorubicin aml
Content Type	Text
Resource Type	Case study
Subject	Medicine

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