Human adenovirus (HAdV) infection in children with acute respiratory tract infections in Guangzhou, China, 2010-2021: a molecular epidemiology study.

Content Provider	Europe PMC
Author	Chen, Yi Lin, Tao Wang, Chang-Bing Liang, Wan-Li Lian, Guang-Wan Zanin, Mark Wong, Sook-San Tian, Xin-Gui Zhong, Jia-Yu Zhang, Ying-Ying Xie, Jia-Hui Zheng, Ling-Ling Chen, Fei-Yan Dang, Run Zhao, Ming-Qi Yang, Yi-Yu Zhou, Rong Zhu, Bing
Abstract	BackgroundHuman adenovirus (HAdV) infection can cause a variety of diseases. It is a major pathogen of pediatric acute respiratory tract infections (ARIs) and can be life-threatening in younger children. We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou, China.MethodsWe conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021. HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis.ResultsBefore the COVID-19 outbreak in Guangzhou, the annual frequency of adenovirus infection detected during this period ranged from 3.92% to 13.58%, with an epidemic peak every four to five years. HAdV demonstrated a clear seasonal distribution, with the lowest positivity in March and peaking during summer (July or August) every year. A significant increase in HAdV cases was recorded for 2018 and 2019, which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7. The latter was associated with a more severe disease compared to HAdV-3. The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38% but increased to 20% in severe cases. After COVID-19 emerged, HAdV cases dropped to 2.68%, suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community.ConclusionOur study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China.
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ISSN	17088569
Journal	World Journal of Pediatrics [World J Pediatr]
Volume Number	18
DOI	10.1007/s12519-022-00590-w
PubMed Central reference number	PMC9302229
Issue Number	8
PubMed reference number	35861938
e-ISSN	18670687
Language	English
Publisher	Springer Nature Singapore
Publisher Date	2022-07-21
Publisher Place	Singapore
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2022
Subject Keyword	Acute respiratory tract infection Children Human adenovirus Severe acute hepatitis Southern China
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health