[¹⁸F]THK-5351 PET Patterns in Patients With Alzheimer's Disease and Negative Amyloid PET Findings.

Content Provider	Europe PMC
Author	Oh, Minyoung Oh, Jungsu S. Oh, Seung Jun Lee, Sang Ju Roh, Jee Hoon Kim, Woo Ram Seo, Ha-Eun Kang, Jae Myeong Seo, Sang Won Lee, Jae-Hong Na, Duk L. Noh, Young Kim, Jae Seung
Copyright Year	2022
Abstract	Background and PurposeAlzheimer’s disease (AD) does not always mean amyloid positivity. [18F]THK-5351 has been shown to be able to detect reactive astrogliosis as well as tau accompanied by neurodegenerative changes. We evaluated the [18F]THK-5351 retention patterns in positron-emission tomography (PET) and the clinical characteristics of patients clinically diagnosed with AD dementia who had negative amyloid PET findings.MethodsWe performed 3.0-T magnetic resonance imaging, [18F]THK-5351 PET, and amyloid PET in 164 patients with AD dementia. Amyloid PET was visually scored as positive or negative. [18F]THK-5351 PET were visually classified as having an intratemporal or extratemporal spread pattern.ResultsThe 164 patients included 23 (14.0%) who were amyloid-negative (age 74.9±8.3 years, mean±standard deviation; 9 males, 14 females). Amyloid-negative patients were older, had a higher prevalence of diabetes mellitus, and had better visuospatial and memory functions. The frequency of the apolipoprotein E ε4 allele was higher and the hippocampal volume was smaller in amyloid-positive patients. [18F]THK-5351 uptake patterns of the amyloid-negative patients were classified into intratemporal spread (n=10) and extratemporal spread (n=13). Neuropsychological test results did not differ significantly between these two groups. The standardized uptake value ratio of [18F]THK-5351 was higher in the extratemporal spread group (2.01±0.26 vs. 1.61±0.15, p=0.001). After 1 year, Mini Mental State Examination (MMSE) scores decreased significantly in the extratemporal spread group (-3.5±3.2, p=0.006) but not in the intratemporal spread group (-0.5±2.8, p=0.916). The diagnosis remained as AD (n=5, 50%) or changed to other diagnoses (n=5, 50%) in the intratemporal group, whereas it remained as AD (n=8, 61.5%) or changed to frontotemporal dementia (n=4, 30.8%) and other diagnoses (n=1, 7.7%) in the extratemporal spread group.ConclusionsApproximately 70% of the patients with amyloid-negative AD showed abnormal [18F]THK-5351 retention. MMSE scores deteriorated rapidly in the patients with an extratemporal spread pattern.
ISSN	17386586
Journal	Journal of Clinical Neurology (Seoul, Korea)
Volume Number	18
PubMed Central reference number	PMC9262461
Issue Number	4
PubMed reference number	35796269
e-ISSN	20055013
DOI	10.3988/jcn.2022.18.4.437
Language	English
Publisher	Korean Neurological Association
Publisher Date	2022-07-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2022 Korean Neurological Association
Subject Keyword	[18F]THK-5351 Alzheimer’s disease amyloid neuropsychological test positron-emission tomography
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)