NDLI: Protective Effect of Hydroxygenkwanin against Hair Graying Induced by X-Ray Irradiation and Repetitive Plucking.

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Protective Effect of Hydroxygenkwanin against Hair Graying Induced by X-Ray Irradiation and Repetitive Plucking.

Content Provider	Europe PMC
Author	Taguchi, Nobuhiko Kitai, Ryosuke Ando, Takuya Nishimura, Toshihiro Aoki, Hitomi Kunisada, Takahiro
Copyright Year	2022
Abstract	Hair graying in mice is caused by various injuries such as X-ray radiation and repeated plucking that ultimately damage melanocytes and their stem cells (melanocyte stem cells). In X-ray‒induced hair graying, injuries first manifest as a loss-of-niche function of hair follicular keratinocyte stem cells to maintain melanocyte stem cells. Thus, we hypothesized that hair follicular keratinocyte stem cells could be a practical target to prevent hair graying. In this study, we investigated the in vivo effect of the flavonoid hydroxygenkwanin, which has been shown to exert the best protection on human epidermal keratinocytes against in vitro X-ray‒induced cytological effects, using X-ray‒induced and repeated hair plucking‒induced hair graying mice models. We found that hydroxygenkwanin exerted a remarkable effect in preventing hair graying; however, when receptor Y kinase Kit-mutant mice were used, no prevention effect was observed. Therefore, we propose that Kit signaling might be involved in the hydroxygenkwanin-induced protective effect against hair graying.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9256660&blobtype=pdf
Journal	JID Innovations [JID Innov]
Volume Number	2
DOI	10.1016/j.xjidi.2022.100121
PubMed Central reference number	PMC9256660
Issue Number	4
PubMed reference number	35812723
e-ISSN	26670267
Language	English
Publisher	Elsevier
Publisher Date	2022-03-16
Access Restriction	Open
Rights License	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). © 2022 The Authors
Subject Keyword	DCF, dichlorofluorescein HFKSC, hair follicular keratinocyte stem cell HGK, hydroxygenkwanin KC, keratinocyte McSC, melanocyte stem cell NHEK, normal human epidermal keratinocyte WT, wild type
Content Type	Text
Resource Type	Article
Subject	Dermatology

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