Efficacy of letrozole versus clomiphene citrate on ovulation induction in patients with polycystic ovarian syndrome.

Content Provider	Europe PMC
Author	Khakwani, Mehnaz Parveen, Rashida Yousaf, Shazia Tareen, Ayesha Uzaima
Copyright Year	2022
Abstract	Objectives:To compare the efficacy of letrozole (LTZ) vs clomiphene citrate (CC) for ovulation induction in patients having polycystic ovarian syndrome (PCOS).Methods:This randomized controlled trial was conducted at The Department of Obstetrics & Gynecology, Nishtar Medical University Hospital, Multan, Pakistan from January 2021 to June 2021. A total of 78 women aged 18 to 30 years, diagnosed having PCOS were enrolled. In Group-A, 39 women were given LTZ, 5mg for five days of menstrual cycle. In Group-B, 39 women were given CC, 100mg for five days of menstrual cycle. All patients underwent transvaginal scan (TVS) for the evaluation of efficacy in terms of ovulation induction.Results:Overall mean age was noted to be 25.41±2.84 years. Most of the patients, 51 (65.4%) belonged to rural area of residence. There were 52 (66.7%) patients with BMI less than 25 kg/m2. Overall, mean duration of infertility was found to be 2.62±0.74 years. Among 70 patients who completed the follow ups and analyzed regarding efficacy, in Group-A, efficacy was noted in 23 (59.0%) patients in comparison to 14 (35.9%) in Group-B (p=0.0413). Mean endometrial thickness was significantly better in Group-A versus Group-B (8.1±1.5 mm vs. 6.8±1.9 mm, p=0.0022).Conclusion:Aiming ovulation induction, letrozole in comparison to clomiphene citrate was found to have significantly better efficacy among women having anovulatory PCOS.
ISSN	1682024X
Volume Number	38
PubMed Central reference number	PMC9247780
Issue Number	5
PubMed reference number	35799761
Journal	Pakistan Journal of Medical Sciences [Pak J Med Sci]
e-ISSN	1681715X
DOI	10.12669/pjms.38.5.5565
Language	English
Publisher	Professional Medical Publications
Publisher Date	2022-05-01
Publisher Place	Pakistan
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Pakistan Journal of Medical Sciences
Subject Keyword	Polycystic ovarian syndrome Letrozole Clomiphene citrate
Content Type	Text
Resource Type	Article
Subject	Medicine