Microcirculatory Function in Nonhypertrophic and Hypertrophic Myocardium in Patients With Aortic Valve Stenosis.

Content Provider	Europe PMC
Author	Sabbah, Muhammad Olsen, Niels Thue Minkkinen, Mikko Holmvang, Lene Tilsted, Hans‐Henrik Pedersen, Frants Joshi, Francis R. Ahtarovski, Kiril Sørensen, Rikke Linde, Jesper James Søndergaard, Lars Pijls, Nico Lønborg, Jacob Engstrøm, Thomas
Abstract	BackgroundLeft ventricular hypertrophy (LVH) has often been supposed to be associated with abnormal myocardial blood flow and resistance. The aim of this study was to evaluate and quantify the physiological and pathological changes in myocardial blood flow and microcirculatory resistance in patients with and without LVH attributable to severe aortic stenosis.Methods and ResultsAbsolute coronary blood flow and microvascular resistance were measured using a novel technique with continuous thermodilution and infusion of saline. In addition, myocardial mass was assessed with cardiac magnetic resonance imaging. Fifty‐three patients with aortic valve stenosis were enrolled in the study. In 32 patients with LVH, hyperemic blood flow per gram of tissue was significantly decreased compared with 21 patients without LVH (1.26±0.48 versus 1.66±0.65 mL·min−1·g−1; P=0.018), whereas minimal resistance indexed for left ventricular mass was significantly increased in patients with LVH (63 [47–82] versus 43 [35–63] Wood Units·kg; P=0.014).ConclusionsPatients with LVH attributable to severe aortic stenosis had lower hyperemic blood flow per gram of myocardium and higher minimal myocardial resistance compared with patients without LVH.
Page Count	11
Journal	Journal of the American Heart Association
Volume Number	11
PubMed Central reference number	PMC9238586
Issue Number	9
PubMed reference number	35470693
e-ISSN	20479980
DOI	10.1161/jaha.122.025381
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-04-26
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
Subject Keyword	aortic stenosis cardiac magnetic resonance imaging coronary flow left ventricular hypertrophy microvascular function thermodilution Coronary Circulation
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine