Optic disc area frequency distribution in a large sample of retinographic images.

Content Provider	Europe PMC
Author	Gonzalez-Hernandez, Marta Gonzalez-Hernandez, Daniel Perez-Barbudo, Daniel Gonzalez de la Rosa, Manuel
Copyright Year	2022
Abstract	ObjectiveTo describe a new method to estimate the frequency distribution of optic nerve disc area, using digital retinographic images.Methods and analysisWe analysed 492 023 fundus images obtained with seven fundus cameras, mainly in Caucasian subjects. They were grouped by resolution and zoom. They were automatically segmented by identifying the inner edge of the Elschnig scleral ring. For this purpose, a neural network trained by deep learning previously described was used. The number of pixels contained within the segmentation and their frequency distribution were calculated. The results of each camera, using different number of images, were compared with the global results using the Kolmogorov-Smirnov test to confront frequency distributions.ResultsThe frequency distribution was non-Gaussian, more limited in small sizes than in large ones. If the median is assigned a theoretical value of 1.95 mm2, the 1th, 5th, 25th, 50th, 75th, 95th and 99th percentiles would correspond to 1.29, 1.46, 1.73, 1.95, 2.20, 2.64 and 3.03 mm2 in all the dataset. The overall differences were significant for the smaller series, but for each percentile their mean value was only 0.01 mm2 and the maximum 0.10 mm2, so they can be considered similar for practical purposes in all cameras.ConclusionBy automatically segmenting the edges of the optic nerve and observing the frequency distribution of the number of pixels it delimits, it is possible to estimate the frequency distribution of the disc area in the population as a whole and that of each individual case.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9214362&blobtype=pdf
Journal	BMJ Open Ophthalmology [BMJ Open Ophthalmol]
Volume Number	7
DOI	10.1136/bmjophth-2022-000972
PubMed Central reference number	PMC9214362
Issue Number	1
PubMed reference number	36161846
e-ISSN	23973269
Language	English
Publisher	BMJ Publishing Group
Publisher Date	2022-06-01
Publisher Place	BMA House, Tavistock Square, London, WC1H 9JR
Access Restriction	Open
Rights License	This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Subject Keyword	optic nerve glaucoma anatomy imaging
Content Type	Text
Resource Type	Article
Subject	Ophthalmology