Exploring the contributing factors to multiple chemical sensitivity in patients with migraine.

Content Provider	Europe PMC
Author	Suzuki, Keisuke Okamura, Madoka Haruyama, Yasuo Suzuki, Shiho Shiina, Tomohiko Kobashi, Gen Hirata, Koichi
Abstract	AbstractObjectiveMultiple chemical sensitivity (MCS) is a form of chemical intolerance in which various systemic symptoms are triggered by exposure to a variety of chemical substances. Although migraine has been associated with central sensitivity syndrome, the relationship between MCS and migraine has not been studied. We assessed the frequency of MCS and its related factors in patients with migraine.MethodsWe performed a cross‐sectional study that included 95 patients (14 M/81 F; age, 45.4 ± 12.4 years) out of 100 consecutive patients with migraine from our outpatient headache clinic. MCS was defined as having a combination of Q1 ≥ 30, Q3 ≥ 13, and Q5 ≥ 17 on the quick environment exposure sensitivity inventory (QEESI; Japanese version). Central sensitization inventory‐A scores >40 were considered an indication of central sensitization. Headache‐related disability and psychological distress were evaluated with the Migraine Disability Assessment score (MIDAS) and Kessler Psychological Distress Scale (K6), respectively.ResultsMCS was identified in 20% of patients with migraine; however, none had previously been diagnosed with MCS. The MCS‐positive group had higher rates of photophobia, osmophobia, visual aura, sensory aura, and central sensitization and higher MIDAS and K6 scores than the MCS‐negative group. A logistic regression analysis showed that osmophobia, sensory aura, and central sensitization were significant contributors to MCS.ConclusionWe showed that MCS was observed in 20% of patients with migraine, and our study results may indicate a possible association of MCS with central sensitization and hypersensitivity‐related symptoms in patients with migraine.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9176718&blobtype=pdf
Page Count	7
ISSN	13419145
Journal	Journal of Occupational Health [J Occup Health]
Volume Number	64
DOI	10.1002/1348-9585.12328
PubMed Central reference number	PMC9176718
Issue Number	1
PubMed reference number	35363938
e-ISSN	13489585
Language	English
Publisher	John Wiley and Sons Inc.
Publisher Date	2022-01-01
Publisher Place	Hoboken
Access Restriction	Open
Rights License	This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2022 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health.
Subject Keyword	headache‐related disability hypersensitivity migraine multiple chemical sensitivity stress
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health