Effects of Vagus Nerve Stimulation on Sleep-Disordered Breathing, Daytime Sleepiness, and Sleep Quality in Patients With Drug-Resistant Epilepsy.

Content Provider	Europe PMC
Author	Kim, Jeong Sik Lee, Do Eon Bae, Hyoeun Song, Joo Yeon Yang, Kwang Ik Hong, Seung Bong
Copyright Year	2022
Abstract	Background and PurposeThis study aimed to determine the long-term effects of vagus nerve stimulation (VNS) on sleep-disordered breathing (SDB), daytime sleepiness, and sleep quality in patients with drug-resistant epilepsy (DRE). It also investigated the relationships among these main effects, clinical characteristics, and VNS parameters.MethodsTwenty-four patients were recruited. Paired t-tests and multiple linear regression analyses were performed to determine how the demographic and clinical characteristics of the patients influenced the variables that changed significantly after VNS treatment.ResultsAfter VNS, the patients showed significant increases in the apnea-hypopnea index (AHI), respiratory disturbance index (RDI), apnea index, hypopnea index, and oxygen desaturation index (ODI), as well as a significant decrease in the lowest arterial oxygen saturation (SaO2 nadir) (p<0.05). The multiple linear regression analyses demonstrated that the predictor of larger increases in AHI and RDI was being older at baseline, and that the predictor of a larger increase in apnea index was a longer epilepsy duration. The strongest predictor of a larger increase in ODI was a higher frequency of aura episodes at baseline, followed by a longer epilepsy duration. The strongest predictor of a larger decrease in SaO2 nadir was a higher frequency of aura episodes at baseline, followed by a longer epilepsy duration.ConclusionsThis study has confirmed that VNS improves seizure control in patients with DRE, whereas it increases obstructive sleep apnea (OSA). Furthermore, the increase in OSA is affected by age and the duration of epilepsy. Therefore, careful observation and monitoring of SDB is recommended in patients who undergo VNS.
ISSN	17386586
Journal	Journal of Clinical Neurology (Seoul, Korea)
Volume Number	18
PubMed Central reference number	PMC9163944
Issue Number	3
PubMed reference number	35589319
e-ISSN	20055013
DOI	10.3988/jcn.2022.18.3.315
Language	English
Publisher	Korean Neurological Association
Publisher Date	2022-05-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2022 Korean Neurological Association
Subject Keyword	epilepsy vagus nerve stimulation obstructive sleep apnea apnea-hypopnea index excessive daytime sleepiness
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)