The log odds of positive neck lymph nodes is a superior lymph node predictor for overall survival in head and neck cancer: a population-based analysis in Germany.

Content Provider	Europe PMC
Author	Kouka, Mussab Al-Ahmar, Elisa Büntzel, Jens Kaftan, Holger Böger, Daniel Müller, Andreas Schultze-Mosgau, Stefan Ernst, Thomas Guntinas-Lichius, Orlando
Abstract	BackgroundThis population-based study investigated the influence of different lymph node (LN) classifications on overall survival (OS) in head and neck cancer (HNC).Methods401 patients (median age: 57 years; 47% stage IV) of the Thuringian cancer registries with diagnosis of a primary HNC receiving a neck dissection (ND) in 2009 and 2010 were included. OS was assessed in relation to total number of LN removed, number of positive LN, LN ratio, and log odds of positive LN (LODDS).ResultsMean number of LODDS was 0–0.96 ± 0.57. When limiting the multivariate analysis to TNM stage, only the UICC staging (stage IV: HR 9.218; 95% CI 2.721–31.224; p < 0.001) and LODDS >  – 1.0 (HR 2.120; 95% CI 1.129–3.982; p = 0.019) were independently associated with lower OS.ConclusionLODDS was an independent and superior predictor for OS in HNC in a population-based setting with representative real-life data.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00405-021-07176-8.
ISSN	09374477
Journal	European Archives of Oto-Rhino-Laryngology
Volume Number	279
PubMed Central reference number	PMC9130179
Issue Number	7
PubMed reference number	34807283
e-ISSN	14344726
DOI	10.1007/s00405-021-07176-8
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2021-11-22
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Head and neck cancer Tumor staging Cancer registry Cervical lymph node metastases Lymph node classifications Survival
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology