A validation study of an esophageal probe-based polygraph against polysomnography in obstructive sleep apnea.

Content Provider	Europe PMC
Author	Olafsson, Thorarinn Arnar Steinsvik, Eivind Andreas Bachmann-Harildstad, Gregor Hrubos-Strøm, Harald
Abstract	Study objectivesThe aim of this study was to validate the automatically scored results of an esophageal probe–based polygraph system (ApneaGraph® Spiro) against manually scored polysomnography (Nox A1, PSG) results. We compared the apnea–hypopnea index, oxygen saturation index, and respiratory disturbance index of the devices.MethodsConsenting patients, referred for obstructive sleep apnea workup, were tested simultaneously with the ApneaGraph® Spiro and Nox A1® polysomnograph. Each participant made one set of simultaneous registrations for one night. PSG results were scored independently. Apnea–hypopnea index, oxygen desaturation index, and respiratory disturbance index were compared using Pearson’s correlation and scatter plots. Sensitivity, specificity, and positive likelihood ratio of all indices at 5, 15, and 30 were calculated.ResultsA total of 83 participants had successful registrations. The apnea–hypopnea index showed sensitivity of 0.83, specificity of 0.95, and a positive likelihood ratio of 5.11 at an index cutoff of 15. At a cutoff of 30, the positive likelihood ratio rose to 31.43. The respiratory disturbance index showed high sensitivity (> 0.9) at all cutoffs, but specificity was below 0.5 at all cutoffs. Scatterplots revealed overestimation in mild OSA and underestimation in severe OSA for all three indices.ConclusionsThe ApneaGraph® Spiro performed acceptably when OSA was defined by an AHI of 15. The equipment overestimated mild OSA and underestimated severe OSA, compared to the PSG.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9130176&blobtype=pdf
ISSN	15209512
Journal	Sleep & Breathing = Schlaf & Atmung [Sleep Breath]
Volume Number	26
DOI	10.1007/s11325-021-02374-4
PubMed Central reference number	PMC9130176
Issue Number	2
PubMed reference number	34181175
e-ISSN	15221709
Language	English
Publisher	Springer International Publishing
Publisher Date	2021-06-28
Publisher Place	Gewerbestrasse 11, Cham, Ch 6330, Switzerland
Access Restriction	Open
Rights License	Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021
Subject Keyword	Obstructive sleep apnea Polysomnography Oximetry Home sleep apnea testing Validation Sleep disordered breathing
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Neurology (clinical)