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Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases: overview and future considerations from the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT).
| Content Provider | Europe PMC |
|---|---|
| Author | Alexander, Tobias Greco, Raffaella |
| Abstract | Autoimmune diseases (ADs) represent a heterogenous group of complex diseases with increasing incidence in Western countries and are a major cause of morbidity. Hematopoietic stem cell transplantation (HSCT) has evolved over the last 25 years as a specific treatment for patients with severe ADs, through eradication of the pathogenic immunologic memory and profound immune renewal. HSCT for ADs is recently facing a unique developmental phase across transplant centers. This review provides a comprehensive overview of the recent evidence and developments in the area, including fundamentals of preclinical research, clinical studies in neurologic, rheumatologic and gastroenterologic diseases, which represent major indications at present, along with evidence of HSCT for rarer indications. Moreover, we describe the interwoven challenges of delivering more advanced cellular therapies, exploiting mesenchymal stem cells, regulatory T cells and potentially CAR-T cell therapies, in patients affected by ADs. Overall, we discuss past and current indications, efficacy, associated risks and benefits, and future directions of HSCT and advanced cellular therapies in the treatment of severe/refractory ADs, integrating the available literature with European Society for Blood and Marrow Transplantation (EBMT) registry data. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9109750&blobtype=pdf |
| ISSN | 02683369 |
| Journal | Bone Marrow Transplantation [Bone Marrow Transplant] |
| Volume Number | 57 |
| DOI | 10.1038/s41409-022-01702-w |
| PubMed Central reference number | PMC9109750 |
| Issue Number | 7 |
| PubMed reference number | 35578014 |
| e-ISSN | 14765365 |
| Language | English |
| Publisher | Nature Publishing Group UK |
| Publisher Date | 2022-05-16 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2022 |
| Subject Keyword | Autoimmune diseases Immunotherapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Transplantation |
