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The frontal aslant tract and its role in executive functions: a quantitative tractography study in glioma patients.
| Content Provider | Europe PMC |
|---|---|
| Author | Landers, Maud J. F. Meesters, Stephan P. L. van Zandvoort, Martine de Baene, Wouter Rutten, Geert-Jan M. |
| Abstract | Focal white matter lesions can cause cognitive impairments due to disconnections within or between networks. There is some preliminary evidence that there are specific hubs and fiber pathways that should be spared during surgery to retain cognitive performance. A tract potentially involved in important higher-level cognitive processes is the frontal aslant tract. It roughly connects the posterior parts of the inferior frontal gyrus and the superior frontal gyrus. Functionally, the left frontal aslant tract has been associated with speech and the right tract with executive functions. However, there currently is insufficient knowledge about the right frontal aslant tract’s exact functional importance. The aim of this study was to investigate the role of the right frontal aslant tract in executive functions via a lesion-symptom approach. We retrospectively examined 72 patients with frontal glial tumors and correlated measures from tractography (distance between tract and tumor, and structural integrity of the tract) with cognitive test performances. The results indicated involvement of the right frontal aslant tract in shifting attention and letter fluency. This involvement was not found for the left tract. Although this study was exploratory, these converging findings contribute to a better understanding of the functional frontal subcortical anatomy. Shifting attention and letter fluency are important for healthy cognitive functioning, and when impaired they may greatly influence a patient’s wellbeing. Further research is needed to assess whether or not damage to the right frontal aslant tract causes permanent cognitive impairments, and consequently identifies this tract as a critical pathway that should be taken into account during neurosurgical procedures. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9107421&blobtype=pdf |
| ISSN | 19317557 |
| Journal | Brain Imaging and Behavior [Brain Imaging Behav] |
| Volume Number | 16 |
| DOI | 10.1007/s11682-021-00581-x |
| PubMed Central reference number | PMC9107421 |
| Issue Number | 3 |
| PubMed reference number | 34716878 |
| e-ISSN | 19317565 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2021-10-30 |
| Publisher Place | New York |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2021 |
| Subject Keyword | Frontal aslant tract Lesion-symptom study Tractography Executive functions Glioma patients |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Radiology, Nuclear Medicine and Imaging Cognitive Neuroscience Behavioral Neuroscience Neurology (clinical) Cellular and Molecular Neuroscience Psychiatry and Mental Health |
