Quality of Life after Rectal Cancer Resection Comparing Anterior Resection, Abdominoperineal Resection, and Complicated Cases.

Content Provider	Europe PMC
Author	Scheele, Jan Lemke, Johannes Wittau, Mathias Sander, Silvia Henne-Bruns, Doris Kornmann, Marko
Copyright Year	2022
Abstract	Introduction Compared to abdominoperineal resection (APR), sphincter preservation using low anterior resection (AR) for rectal cancer (RC) implies the risk of impaired functional outcome and postoperative complications associated with a persistent or additionally required ostomy. The aim of our study was to compare quality of life (QoL) after AR and APR with a special separate analysis of AR patients with a stoma. Methods QoL of 84 APR, 356 AR, and 29 AR patients with complications and an additional stoma, termed converted therapy (COT) patients, was compared with regard to groups and effect of radiotherapy (RT). All patients received rectal resection between 1998 and 2013, and 47% of the patients had RT. QoL was assessed using extended EORTC QLQ-C30 and -CR38 questionnaires. Results Questionnaires from 57 APR, 165 AR, and 25 COT patients alive were evaluated after a median time of 4 years after surgery. Global health status was equally high in AR and APR patients (score: 67), whereas COT patients turned out with a significantly lower score of 50 (p = 0.007). Compared to APR and COT, AR patients revealed less symptoms and higher functionality, especially for physical, role, and social functioning (p < 0.001). The reduction of QoL instances was significant in the COT group and in all patients treated by RT. Conclusion QoL after RC resection may be further improved by avoiding additionally required ostomy after AR but also RT by a better individual selection of qualified patients. Qualification parameters urgently need to be defined by prospective studies.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9082171&blobtype=pdf
Page Count	12
ISSN	22974725
Volume Number	38
DOI	10.1159/000520945
PubMed Central reference number	PMC9082171
Issue Number	2
PubMed reference number	35614891
Journal	Visceral Medicine [Visc Med]
e-ISSN	2297475X
Language	English
Publisher	Karger Publishers
Publisher Date	2022-01-17
Publisher Place	Allschwilerstrasse 10, CH-4055 Basel, Switzerland
Access Restriction	Open
Rights License	Copyright © 2022 by S. Karger AG, Basel
Subject Keyword	Quality of life Rectal cancer Total mesorectal excision Low anterior resection Abdominoperineal resection Stoma
Content Type	Text
Resource Type	Article
Subject	Gastroenterology Surgery