The Prognostic Value of Thyroid-Stimulating Hormone in Patients with Coronary Artery Disease and Depression.

Content Provider	Europe PMC
Author	Li, Weiya Qiu, Di Yin, Han Wang, Yu Chen, Yilin Liu, Quanjun Ma, Huan Geng, Qingshan
Copyright Year	2022
Abstract	PurposePatients with the comorbidity of coronary artery disease (CAD) and depression are very common and always have poor prognosis. The relationship between thyroid-stimulating hormone (TSH) levels and major cardiovascular event (MACE) in these patients is still unknown. We aimed to explore this association.Patients and MethodsWe enrolled 203 CAD patients proven by coronary angiography (CAG). In the meanwhile, they were all assessed to have depression symptom by professional psycho-cardiologists. After an average follow-up of 23.7 months, patients were divided into two groups (high TSH group with TSH ≥ 1.395μIU/mL and low TSH group with TSH < 1.395μIU/mL) according to the cut-off value of baseline TSH. The impact of two different TSH groups for adverse events in CAD patients with depression was evaluated.ResultsThe average age of these patients was 64.9 years old. The two TSH groups had no significant difference in the comparison of other baseline data. Area under the receiver operating characteristic (ROC) curves (AUC) analysis indicated the well-discriminatory power of TSH levels for the occurrence of MACE (AUC = 0.61, 95% CI: 0.52–0.70, P = 0.03). In the KM survival analysis, high TSH group had a higher risk of MACE (P = 0.029). After multi-factor adjustment, there still existed a higher risk of MACE in high TSH group (HR = 2.05, 95% CI: 1.08–3.88, P = 0.028).ConclusionIn patients with the comorbidity of CAD and depression, higher TSH levels are associated with the occurrence of MACE. More researches need to be conducted to prove this association and explore whether the drug-related TSH reduction can decrease the occurrence of adverse events in the future.
Page Count	9
Volume Number	15
PubMed Central reference number	PMC9081036
PubMed reference number	35548588
Journal	International Journal of General Medicine [Int J Gen Med]
e-ISSN	11787074
DOI	10.2147/IJGM.S364146
Language	English
Publisher	Dove
Publisher Date	2022-05-04
Access Restriction	Open
Rights License	This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). © 2022 Li et al.
Subject Keyword	thyroid-stimulating hormone TSH coronary artery disease CAD depression MACE
Content Type	Text
Resource Type	Article
Subject	Medicine