NDLI: PolyJet-Based 3D Printing against Micromolds to Produce Channel Structures for Microchip Electrophoresis.

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PolyJet-Based 3D Printing against Micromolds to Produce Channel Structures for Microchip Electrophoresis.

Content Provider	Europe PMC
Author	Selemani, MajorA. Castiaux, Andre D. Martin, R. Scott
Copyright Year	2022
Abstract	In this work, wedemonstrate the ability to use micromolds alongwith a stacked three-dimensional (3D) printing process on a commerciallyavailable PolyJet printer to fabricate microchip electrophoresis devicesthat have a T-intersection, with channel cross sections as small as48 × 12 μm2 being possible. The fabricationprocess involves embedding removable materials or molds during theprinting process, with various molds being possible (wires, brassmolds, PDMS molds, or sacrificial materials). When the molds are delaminated/removed,recessed features complementary to the molds are left in the 3D prints.A thermal lab press is used to bond the microchannel layer that alsocontains printed reservoirs against another solid 3D-printed partto completely seal the microchannels. The devices exhibited cathodicelectroosmotic flow (EOF), and mixtures of fluorescein isothiocyanateisomer I (FITC)-labeled amino acids were successfully separated onthese 3D-printed devices using both gated and pinched electrokineticinjections. While this application is focused on microchip electrophoresis,the ability to 3D-print against molds that can subsequently be removedis a general methodology to decrease the channel size for other applicationsas well as to possibly integrate 3D printing with other productionprocesses.
Journal	ACS Omega
Volume Number	7
PubMed Central reference number	PMC9026087
Issue Number	15
PubMed reference number	35474767
e-ISSN	24701343
DOI	10.1021/acsomega.2c01265
Language	English
Publisher	American Chemical Society
Publisher Date	2022-04-08
Access Restriction	Open
Rights License	Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). © 2022 The Authors. Published by American Chemical Society
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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