Efficacy and Safety of Thoracic Epidural Analgesia in Patients With Acute Pancreatitis: A Narrative Review.

Content Provider	Europe PMC
Author	Nair, Abhijit Tiwary, Manish Kumar Seelam, Suresh Kotthapalli, Krishna Kishore Pulipaka, Kaushik
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2022
Abstract	Patients admitted to the intensive care unit with moderate to severe acute pancreatitis carry significant morbidity and mortality. A few unfortunate patients in whom the initial line of treatment fails to show clinical improvement develop multiorgan dysfunction involving lungs (adult respiratory distress syndrome), renal failure, intra-abdominal infections, sepsis, and septic shock, which ultimately leads to prolonged hospitalization and a substantial cost of treatment. The acute abdominal pain experienced by these patients is excruciating and requires multimodal analgesia. Continuous epidural analgesia has been found to provide good quality, opioid-sparing analgesia in these patients. A few studies have also demonstrated that segmental sympathectomy resulting from epidural blockade could lead to lowering of serum amylase and lipase levels improve paralytic ileus, and thus hastens the process of recovery. The present paper aims to discuss the advantages of continuous epidural analgesia in patients with acute pancreatitis of varying severity and to review the existing literature using specific keywords.
Journal	Cureus
Volume Number	14
DOI	10.7759/cureus.23234
PubMed Central reference number	PMC9012692
Issue Number	3
PubMed reference number	35449658
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2022-03-16
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	neuraxial analgesia severe acute pancreatitis intensive care unit thoracic epidural analgesia acute pain management
Content Type	Text
Resource Type	Article
Subject	Medicine