NDLI: Poorly differentiated thyroid carcinoma: a clinician's perspective.

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Poorly differentiated thyroid carcinoma: a clinician's perspective.

Content Provider	Europe PMC
Author	Tong, Junyu Ruan, Maomei Jin, Yuchen Fu, Hao Cheng, Lin Luo, Qiong Liu, Zhiyan Lv, Zhongwei Chen, Libo
Copyright Year	2022
Abstract	Poorly differentiated thyroid carcinoma (PDTC) is a rare thyroid carcinoma originating from follicular epithelial cells. No explicit consensus can be achieved to date due to sparse clinical data, potentially compromising the outcomes of patients. In this comprehensive review from a clinician’s perspective, the epidemiology and prognosis are described, diagnosis based on manifestations, pathology, and medical imaging are discussed, and both traditional and emerging therapeutics are addressed as well. Turin consensus remains the mainstay diagnostic criteria for PDTC, and individualized assessments are decisive for treatment option. The prognosis is optimal if complete resection is performed at early stage but dismal in nearly half of patients with locally advanced and/or distant metastatic diseases, in which adjuvant therapies such as 131I therapy, external beam radiation therapy, and chemotherapy should be incorporated. Emerging therapeutics including molecular targeted therapy, differentiation therapy, and immunotherapy deserve further investigations to improve the prognosis of PDTC patients with advanced disease.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9010806&blobtype=pdf
ISSN	22350640
Journal	European Thyroid Journal [Eur Thyroid J]
Volume Number	11
PubMed Central reference number	PMC9010806
Issue Number	2
PubMed reference number	35195082
e-ISSN	22350802
DOI	10.1530/etj-22-0021
Language	English
Publisher	Bioscientifica Ltd
Publisher Date	2022-03-24
Publisher Place	Bristol
Access Restriction	Open
Rights License	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. © The authors
Subject Keyword	poorly differentiated thyroid carcinoma PDTC
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism

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