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Remdesivir in Coronavirus Disease 2019 patients treated with anti-CD20 monoclonal antibodies: a case series.
| Content Provider | Europe PMC |
|---|---|
| Author | Rüfenacht, Susanne Gantenbein, Pascal Boggian, Katia Flury, Domenica Kern, Lukas Dollenmaier, Günter Kohler, Philipp Albrich, Werner C. |
| Abstract | PurposeCOVID-19 patients on anti-CD20 treatment can suffer a delayed viral clearance and worse clinical outcome. We aim to present our experience with remdesivir treatment in anti-CD20-treated patients with prolonged symptoms, a patient population for which no data from randomized controlled trials are available.MethodsFrom the beginning of the pandemic until February 2021, we included all consecutive patients from our healthcare network on anti-CD20 treatment with prolonged COVID-19 symptoms, who received remdesivir. Patient informed consent was gathered and patients’ charts were reviewed to collect baseline data, COVID-19 history including time of symptom onset, diagnosis, data on treatment and disease course. Patients or their next of kin were contacted in March 2022 to assess long-term outcomes.ResultsWe included 11 patients, who received remdesivir at a median of 33 days after diagnosis. Eight patients showed clinical improvement along with reductions in viral loads, one patient with relapsing infection recovered after administration of convalescent plasma, and two patients died. No clinical relapses were reported (median follow-up 13 months), while follow-up PCRs were not performed. One patient died of underlying malignancy 8 months after recovery from COVID-19.ConclusionsWe observed a benefit of antiviral therapy in a majority of COVID-19 patients on anti-CD20 treatment, without any clinical relapses in the 1-year follow-up. Although these data suggest that remdesivir might be a promising management option in patients with delayed viral clearance, the lack of a control group is an important limitation of the study design.Trial registrationEthikkommission Ostschweiz, Scheibenackerstrasse 4, CH-9000 St. Gallen approved this case series. Project-ID 2021-00349 EKOS 21/027. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9010446&blobtype=pdf |
| ISSN | 03008126 |
| Journal | Infection |
| Volume Number | 50 |
| DOI | 10.1007/s15010-022-01821-y |
| PubMed Central reference number | PMC9010446 |
| Issue Number | 3 |
| PubMed reference number | 35426564 |
| e-ISSN | 14390973 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2022-04-15 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | Open |
| Rights License | This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022 |
| Subject Keyword | COVID-19 SARS-CoV-2 Anti-CD20 antibodies Rituximab Remdesivir |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology (medical) |
