NDLI: Insights into nervous system repair from the fruit fly.

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Insights into nervous system repair from the fruit fly.

Content Provider	Europe PMC
Author	Coupe, David Bossing, Torsten
Copyright Year	2022
Abstract	Abstract Millions of people experience injury to the central nervous system (CNS) each year, many of whom are left permanently disabled, providing a challenging hurdle for the field of regenerative medicine. Repair of damage in the CNS occurs through a concerted effort of phagocytosis of debris, cell proliferation and differentiation to produce new neurons and glia, distal axon/dendrite degeneration, proximal axon/dendrite regeneration and axon re-enwrapment. In humans, regeneration is observed within the peripheral nervous system, while in the CNS injured axons exhibit limited ability to regenerate. This has also been described for the fruit fly Drosophila. Powerful genetic tools available in Drosophila have allowed the response to CNS insults to be probed and novel regulators with mammalian orthologs identified. The conservation of many regenerative pathways, despite considerable evolutionary separation, stresses that these signals are principal regulators and may serve as potential therapeutic targets. Here, we highlight the role of Drosophila CNS injury models in providing key insight into regenerative processes by exploring the underlying pathways that control glial and neuronal activation in response to insult, and their contribution to damage repair in the CNS.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9008705&blobtype=pdf
Page Count	17
Volume Number	6
PubMed Central reference number	PMC9008705
Issue Number	1
PubMed reference number	35474685
Journal	Neuronal Signaling [Neuronal Signal]
e-ISSN	20596553
DOI	10.1042/ns20210051
Language	English
Publisher	Portland Press Ltd.
Publisher Date	2022-04-13
Access Restriction	Open
Rights License	This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). © 2022 The Author(s).
Subject Keyword	axon regrowth axonal injury cell proliferation CNS damaga glial injury
Content Type	Text
Resource Type	Article
Subject	Cellular and Molecular Neuroscience

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