Antibody persistence upto 5 years after primary immunization and booster with an inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children.

Content Provider	Europe PMC
Author	Hattasingh, Weerawan Chanthavanich, Pornthep Sirivichayakul, Chukiat Arunsodsai, Watcharee Surangsrirat, Surachai Srisuwannaporn, Termsang Kaewma, Benjawan Yoksan, Sutee Limkittikul, Kriengsak Yang, Junwei Mao, Yu
Copyright Year	2022
Abstract	Japanese encephalitis is the main cause of viral encephalitis in Asia. In a previous single-arm vaccine trial, an inactivated chromatographically purified Japanese encephalitis Vero cell vaccine (CVI-JE; JEVACTM) was safe and immunogenic in 152 Thai children aged 1–3 years receiving a 2-dose primary immunization and booster dose 1 year later. We conducted a 5-year follow-up assessment of the persistence of the immune response the 144 children remaining in this cohort after first booster dose. Immunity was assessed by 50% plaque reduction neutralization test annually for up to 5 years post-booster. Seroprotection rates (95%CI) decreased from 100% (97.1–100) at 1 year post-booster to 93% (85.0–98.3) at 5 years post-booster. No serious vaccine-related adverse events or Japanese encephalitis infections were reported. A 2-dose primary immunization and booster 1 year later with CVI-JE provided long-lasting immunity in the majority of children.
Page Count	6
ISSN	21645515
Journal	Human Vaccines & Immunotherapeutics
Volume Number	18
PubMed Central reference number	PMC8993053
Issue Number	1
PubMed reference number	35103548
e-ISSN	2164554X
DOI	10.1080/21645515.2022.2028513
Language	English
Publisher	Taylor & Francis
Publisher Date	2022-02-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
Subject Keyword	Children chromatographical purify inactivated Vero cell-derived vaccine immunogenicity Japanese encephalitis vaccine long-term follow-up
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Pharmacology Immunology