Molecular Markers in the Diagnosis of Thyroid Cancer in Indeterminate Thyroid Nodules.

Content Provider	Europe PMC
Author	Kannan, Subramanian
Abstract	The Bethesda System for the Reporting of Thyroid Cytology recognises six diagnostic categories of thyroid nodule cytology with an incremental risk of malignancy. Although the Bethesda system created a much-needed handhold by standardising the cytological diagnosis and management of thyroid nodules worldwide, the system does not provide a clear answer to the heterogeneous group of nodules with indeterminate cytology. Improvement in the assessment of indeterminate fine-needle aspiration (FNA) results with molecular testing allows better risk stratification and reduces the need for diagnostic thyroid surgery. The molecular markers are classified as a “rule out” test, which has a high negative predictive value and helpful in cases with a low pre-test probability of cancer to rule out thyroid cancer. The “rule in” test has a high positive predictive value and helps in confirming malignancy in those with a high pre-test probability of cancer. This review summarises the commonly used molecular studies in thyroid FNAC aspirates and their current role in clinical practice.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8986925&blobtype=pdf
ISSN	09757651
Volume Number	13
DOI	10.1007/s13193-020-01112-8
PubMed Central reference number	PMC8986925
Issue Number	1
PubMed reference number	35462643
Journal	Indian Journal of Surgical Oncology [Indian J Surg Oncol]
e-ISSN	09766952
Language	English
Publisher	Springer India
Publisher Date	2020-06-06
Publisher Place	New Delhi
Access Restriction	Open
Rights License	© Indian Association of Surgical Oncology 2020
Subject Keyword	Inderterminate thyroid modules Molecular markers Thyroid cancer
Content Type	Text
Resource Type	Article
Subject	Surgery Oncology