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Sublingual misoprostol versus manual vacuum aspiration for treatment of incomplete abortion in Nigeria: a randomized control study.
| Content Provider | Europe PMC |
|---|---|
| Author | Ani, Vincent Chinedu Enebe, Joseph Tochukwu Dim, Cyril Chukwudi Dim, Ngozi Regina Ozumba, Benjamin Chukwuma |
| Copyright Year | 2022 |
| Abstract | Introductionsingle-dose of sublingual misoprostol 400mcg with the participant followed-up at the gynecology clinic one week after with an ultrasound scan for the completeness of the uterine evacuation. Objective: to compare the effectiveness of single-dose sublingual misoprostol to manual vacuum aspiration in the treatment of incomplete spontaneous abortion in Enugu, Nigeria.Methodsthe primary outcome measure was the incidence of complete uterine evacuation (complete abortion) after one week of treatment while the secondary outcome measures included incidence, types, and tolerability of treatment side effects as well as participants' satisfaction with the treatment received.Resultstwo hundred and three participants who met the study criteria and completed the study were randomised into the intervention group (n=102) received single-dose sublingual misoprostol 400mcg and the control group (n= 101) received manual vacuum aspiration. Incidence of complete abortion was 86.3% for the misoprostol group and 100.0% for the control group, RR = 0.86, (CI 95%: 0.80 - 0.93), p <0.001. The most common side effect was abdominal pain with an incidence of 27.5% versus 48.55 for the misoprostol and control groups respectively (p = 0.002). Most participants in each group (81.1% versus 77.6% for the misoprostol and control groups respectively) considered the side effects as tolerable. The mean visual analogue scale score for maternal satisfaction was higher in the misoprostol group (86.7 ± 14.11) than the control group (81.36 ± 11.10), p < 0.001.Conclusionthe treatment of incomplete spontaneous abortion with single-dose sublingual misoprostol 400mcg produced a high rate of complete abortion among women in Enugu, Nigeria. Despite having a lower complete abortion rate, maternal satisfaction was higher when compared with women that had manual vacuum aspiration of the uterus. Trial registration: trial registration number - PACTR202009857889210, date of registration - September 23rd, 2020. Retrospectively registered. |
| Journal | The Pan African Medical Journal |
| Volume Number | 41 |
| PubMed Central reference number | PMC8977358 |
| PubMed reference number | 35432695 |
| e-ISSN | 19378688 |
| DOI | 10.11604/pamj.2022.41.90.29364 |
| Language | English |
| Publisher | The African Field Epidemiology Network |
| Publisher Date | 2022-02-01 |
| Access Restriction | Open |
| Rights License | The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: Vincent Chinedu Ani et al. |
| Subject Keyword | Sublingual misoprostol post-abortion care complete abortion manual vacuum aspiration |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
