Self-Assembly of Soluplus in Aqueous Solutions: Characterization and Prospectives on Perfume Encapsulation.

Content Provider	Europe PMC
Author	Sofroniou, Constantina Baglioni, Michele Mamusa, Marianna Resta, Claudio Doutch, James Smets, Johan Baglioni, Piero
Copyright Year	2022
Abstract	Soluplus is an amphiphilicgraft copolymer intensively studiedas a micellar solubilizer for drugs. An extensive characterizationof the nanostructure of its colloidal aggregates is still lacking.Here, we provide insights into the polymer’s self-assemblyin water, and we assess its use as an encapsulating agent for fragrances.The self-assembly properties of Soluplus aqueous solutions were studiedover a wide concentration range (1–70% w/w) by means of small-angleneutron scattering (SANS), differential scanning calorimetry, NMR,and rheometry. SANS analyses revealed the presence of polymeric micelleswith a fuzzy surface interacting via a 2-Yukawa potential, up to 15%w/w polymer. Increasing the polymer concentration up to 55% w/w ledto tightly packed micelles described according to the Teubner–Streymodel. The ability of Soluplus to encapsulate seven perfume molecules,2-phenyl ethanol, l-carvone, linalool, florhydral, β-citronellol,α-pinene, and R-limonene, was then examined.We showed that the fragrance’s octanol/water partition coefficient(log Kow), widely used to characterizethe solubilization capacity, is not sufficient to characterize suchsystems and the presence of specific functional groups or molecularconformation needs to be considered. In fact, the combination of SANS,NMR, confocal laser scanning microscopy, and confocal Raman microscopyshowed that the perfumes, interacting with different regions of thepolymer aggregates, are able to tune the systems’ structuresresulting in micelles, matrix-type capsules, core–shell capsules,or oil-in-water emulsions.
ISSN	19448244
Journal	ACS Applied Materials & Interfaces
Volume Number	14
PubMed Central reference number	PMC8972246
Issue Number	12
PubMed reference number	35312278
e-ISSN	19448252
DOI	10.1021/acsami.2c01087
Language	English
Publisher	American Chemical Society
Publisher Date	2022-03-21
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2022 The Authors. Published by American Chemical Society
Subject Keyword	self-assembly amphiphilic graft-polymer fragrances encapsulation self-assembled capsules small-angleneutron scattering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Materials Science