NDLI: Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Diagnosis in Adolescent and Isotretinoin as a Possible Serious Exacerbating Factor.

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Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Diagnosis in Adolescent and Isotretinoin as a Possible Serious Exacerbating Factor.

Content Provider	Europe PMC
Author	Shahada, Omar O Kurdi, Ahmed S Aljawi, Afnan F Khayat, Lujain I Shahadah, Anas O
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2022
Abstract	Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare auto-inflammatory condition involving cutaneous and osteoarticular manifestations. This study presents a case where a 16-year-old male with glucose-6-phosphate dehydrogenase (G6PD) deficiency presented with severe nodulocystic acne after three weeks of isotretinoin therapy. In addition to worsening acne, the patient had bone and joint pain with movement restriction. The patient's workup showed elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), bilateral symmetrical sacroiliitis on magnetic resonance imaging (MRI), and multiple bony lesions on bone scintigraphy. A diagnosis of SAPHO syndrome possibly induced by isotretinoin was made. Isotretinoin discontinuation, analgesia, topical acne medications, prednisolone, and adalimumab yielded considerable clinical improvement.
Journal	Cureus
Volume Number	14
DOI	10.7759/cureus.22776
PubMed Central reference number	PMC8971070
Issue Number	3
PubMed reference number	35371846
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2022-03-02
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	hyperostosis dermatosis isotretinoin acne conglobata acne vulgaris pustulosis osteitis sacroiliitis synovitis sapho syndrome
Content Type	Text
Resource Type	Case study
Subject	Medicine

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