NDLI: Novel 1, 2, 4-Triazoles as Antifungal Agents.

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Novel 1, 2, 4-Triazoles as Antifungal Agents.

Content Provider	Europe PMC
Author	Kazeminejad, Zahra Marzi, Mahrokh Shiroudi, Abolfazl Kouhpayeh, Seyed Amin Farjam, Mojtaba Zarenezhad, Elham
Copyright Year	2022
Abstract	The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4-Triazole is one of the most essential pharmacophore systems between five-membered heterocycles. The structure-activity relationship (SAR) of this nitrogen-containing heterocyclic compound showed potential antifungal activity. The 1,2,4-triazole core is present as the nucleus in a variety of antifungal drug categories. The most potent and broad activity of triazoles have confirmed them as pharmacologically significant moieties. The goal of this review is to highlight recent developments in the synthesis and SAR study of 1,2,4-triazole as a potential fungicidal compound. In this study, we provide the results of a biological activity evaluation using various structures and figures. Literature investigation showed that 1, 2, 4-triazole derivatives reveal the extensive span of antifungal activity. This review will assist researchers in the development of new potential antifungal drug candidates with high effectiveness and selectivity.
ISSN	23146133
Journal	Biomed Research International
Volume Number	2022
PubMed Central reference number	PMC8964166
PubMed reference number	35360519
e-ISSN	23146141
DOI	10.1155/2022/4584846
Language	English
Publisher	Hindawi
Publisher Date	2022-03-22
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2022 Zahra Kazeminejad et al.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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