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Post-warming embryo morphology is associated with live birth: a cohort study of single vitrified-warmed blastocyst transfer cycles.
| Content Provider | Europe PMC |
|---|---|
| Author | Allen, Meagan Hale, Lyndon Lantsberg, Daniel Kieu, Violet Stevens, John Stern, Catharyn Gardner, David K. Mizrachi, Yossi |
| Abstract | PurposeThis study aims to examine whether blastocyst morphology post-warming correlates with live birth.MethodsIn this cohort study, morphological characteristics post-warming were reviewed in all single vitrified-warmed blastocyst transfer cycles performed between November 2016 and May 2017. Immediately before transfer, the degree of blastocoel re-expansion was graded as A, fully expanded; B, partially expanded ≥ 50%; C, partially expanded < 50%; and D, collapsed. The degree of post-warming cell survival was graded on a scale of 50 to 100% and was then classified into 4 groups: very low 50–70%, low 71–80%, moderate 81–90%, and high 91–100%.ResultsOverall, 612 cycles were reviewed, of which 196 included PGT-A tested embryos. The live birth rate (LBR) increased from 11.4% in the collapsed blastocysts group to 38.9% in the post-warming full re-expansion group (p < 0.001) and from 6.5% for blastocysts with a very low cell survival rate to 34.7% for blastocysts with high cell survival rate (p = 0.001). LBR was 6.7% for blastocysts with the worst post-warming morphological characteristics, namely, collapsed with very low cell survival rate. On multivariate analyses, partial blastocyst re-expansion ≥ 50%, full re-expansion, and high cell survival rate remained significantly associated with live birth, after controlling for female age, pre-vitrification morphological grading, and PGT-A. A sub-analysis of cycles using PGT-A tested embryos showed similar results.ConclusionPost-warming re-expansion and high cell survival rate are associated with higher LBR in euploid and untested blastocysts. However, embryos with poor post-warming morphology still demonstrate a considerable probability of live birth, and they should not be discarded.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10815-021-02390-z. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8956752&blobtype=pdf |
| ISSN | 10580468 |
| Journal | Journal of Assisted Reproduction and Genetics [J Assist Reprod Genet] |
| Volume Number | 39 |
| DOI | 10.1007/s10815-021-02390-z |
| PubMed Central reference number | PMC8956752 |
| Issue Number | 2 |
| PubMed reference number | 35043277 |
| e-ISSN | 15737330 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2022-01-18 |
| Publisher Place | New York |
| Access Restriction | Open |
| Rights License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © Crown 2022 |
| Subject Keyword | IVF Vitrification Grading Warming Blastocyst |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology Embryology Reproductive Medicine Genetics (clinical) Obstetrics and Gynecology |
