Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia.

Content Provider	Europe PMC
Author	Oyenuga, Mosunmoluwa Onyechi, Afoma Sartaj, Sara Patel, Rushin Sinha, Jyotsana
Editor	Muacevic, Alexander Adler, John R
Copyright Year	2022
Abstract	Cyclic thrombocytopenia (CTP) is a very rare hematological disorder that is characterized by periodic fluctuations in platelet counts. Diagnosis is generally delayed due to its similarity with immune thrombocytopenia (ITP). The pathophysiology is unknown and there are currently no guidelines for management. Many patients are usually treated for ITP initially prior to diagnosis. We describe a 67-year-old female with a history of multiple episodes of transient thrombocytopenia who presented to the hospital with another episode of thrombocytopenia. Her workup including HIV, hepatitis screening, vitamin B12, and folate was negative. She received a unit of platelet transfusion and was later observed in the hospital. Further review of her chart showed similar episodes in the past with spontaneous improvement. She was diagnosed with CTP. Her platelet count improved remarkably prior to discharge. In patients with recurrent fluctuation in their platelet count, CTP should be one of the differentials as this might prevent further unnecessary therapies.
Journal	Cureus
Volume Number	14
DOI	10.7759/cureus.22525
PubMed Central reference number	PMC8956483
Issue Number	2
PubMed reference number	35345682
e-ISSN	21688184
Language	English
Publisher	Cureus
Publisher Date	2022-02-23
Publisher Place	Palo Alto (CA)
Access Restriction	Open
Subject Keyword	cyclical thrombocytopenia cyclic thrombocytopenia low platelet count thrombocytopenia ctp
Content Type	Text
Resource Type	Case study
Subject	Medicine