Loading...
Please wait, while we are loading the content...
A Novel Study on the Self-Assembly Behavior of Poly(lactic-co-glycolic acid) Polymer Probed by Curcumin Fluorescence.
| Content Provider | Europe PMC |
|---|---|
| Author | Zakaria, Hanine El Kurdi, Riham Patra, Digambara |
| Copyright Year | 2022 |
| Abstract | Understanding theself-assembly behavior of block copolymers isof great importance due to their usefulness in a wide range of applications.In this work, the physical properties of poly(lactic-co-glycolic acid) (PLGA polymer) are studied for the first time insolution using the fluorescence technique and curcumin as a molecularprobe. First, curcumin at a concentration of 2 μM was addedto different concentrations of PLGA, and the fluorescence of curcuminwas tracked. It was found that the critical micellar concentration(CMC) was equal to 0.31 g/L and the critical micellar temperature(CMT) was obtained to be 25 °C. Furthermore, an insight on theeffect of NaCl salt on the CMC value of PLGA is assessed through curcuminprobing. A decrease in the CMC has been observed with the increasein the concentration of NaCl, which could be due to the salting outeffect. Moreover, in order to understand the aggregation behaviorof PLGA in different solutions, CMC experiments were investigatedusing chloroform as a solvent. Results showed that the solvent doesnot affect the CMC value of the polymer; however, it only affectsthe shape of the obtained micelle forming a reversed micelle. Finally,fluorescence quenching of curcumin with hydrophobic cetyl-pyridiniumbromide (CPB) and hydrophilic KI quenchers was established, whereit was proved that curcumin is located near the hydrophobic pocketof the Stern layer of the PLGA micelle. |
| Journal | ACS Omega |
| Volume Number | 7 |
| PubMed Central reference number | PMC8945179 |
| Issue Number | 11 |
| PubMed reference number | 35350334 |
| e-ISSN | 24701343 |
| DOI | 10.1021/acsomega.1c06919 |
| Language | English |
| Publisher | American Chemical Society |
| Publisher Date | 2022-03-08 |
| Access Restriction | Open |
| Rights License | Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2022 The Authors. Published by American Chemical Society |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Chemical Engineering |
