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Lupus-like nephritis with positive anti-neutrophil cytoplasmic antibodies and negative antinuclear antibodies.
| Content Provider | Europe PMC |
|---|---|
| Author | Santos, Joana Eugénio Vicente, Rita Malvar, Beatriz Santos, Iolanda Coimbra, Miguel Amoedo, Manuel Pires, Carlos |
| Abstract | AbstractAntineutrophil cytoplasmic antibodies (ANCAs) are associated with small vessel vasculitis but their prevalence is not rare in other immune diseases. In lupus nephritis (LN), their pathological role and clinical relevance have been the target of controversial views.We present a case of acute kidney injury and nephrotic syndrome in a young woman with diffuse global proliferative and membranous nephritis on her kidney biopsy, showing a full-house immunofluorescence pattern, very allusive of class IV + V LN, but lacking associated clinical criteria and laboratory findings to support the diagnosis of systemic lupus erythematosus (SLE). Furthermore, the patient presented with high titers of ANCA, steadily decreasing alongside the renal function and proteinuria improvements, with mycophenolate mofetil (MMF) and steroid treatment.The authors believe this is a case of lupus-like nephritis, in which ANCAs are immunological markers, although they are not directly involved in the pathogenesis. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8943873&blobtype=pdf |
| ISSN | 01012800 |
| Journal | Jornal Brasileiro de Nefrologia [J Bras Nefrol] |
| Volume Number | 44 |
| PubMed Central reference number | PMC8943873 |
| Issue Number | 1 |
| PubMed reference number | 33107901 |
| e-ISSN | 21758239 |
| DOI | 10.1590/2175-8239-jbn-2020-0114 |
| Language | English |
| Publisher | Sociedade Brasileira de Nefrologia |
| Publisher Date | 2022-01-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Subject Keyword | Antineutrophil Cytoplasmic Antibodies, Antinuclear Autoantibodies Lupus Nephritis Lupus Erythematosus, Systemic Glomerulonephritis Anticorpos Anticitoplasma de Neutrófilos Anticorpo Antinuclear Nefrite Lúpica Lúpus Eritematoso Sistêmico Glomerulonefrite |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
